The fusion and fission behaviors of exosomes are essential for the cell‐to‐cell communication. Developing exosome‐mimetic vesicles with such behaviors is of vital importance, but still remains a big challenge. Presented herein is an artificial supramolecular vesicle that exhibits redox‐modulated reversible fusion‐fission functions. These vesicles tend to fuse together and form large‐sized vesicles upon oxidation, undergo a fission process and then return to small‐sized vesicles through reduction. Noteworthy, the aggregation‐induced emission (AIE) characteristics of the supramolecular building blocks enable the molecular configuration during vesicular transformation to be monitored by fluorescence technology. Moreover, the presented vesicles are excellent nanocarrier candidates to transfer siRNA into cancer cells.

中文翻译：

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具有可逆和可控制的融合与裂变的外泌体模拟超分子囊泡。

外来体的融合和裂变行为对于细胞间的通信至关重要。开发具有这种行为的仿外泌囊泡至关重要，但仍然是一个巨大的挑战。本文介绍的是一种人造的超分子囊泡，它具有氧化还原调节的可逆融合裂变功能。这些囊泡趋于融合在一起，并在氧化时形成大囊泡，经历裂变过程，然后通过还原返回小囊泡。值得注意的是，超分子构件的聚集诱导发射（AIE）特性使囊泡转化过程中的分子构型能够通过荧光技术进行监测。此外，提出的囊泡是将siRNA转移到癌细胞中的极好的纳米载体候选物。