Abstract Four new potent anticancer palladium(II) complexes containing PdClPS2 coordination sphere have been synthesized and characterized by different analytical techniques. Here, P is the donor atom from organophosphine (triphenylphosphine (1 and 3) and tris(p-chlorophenyl)phosphine (2 and 4)) and S2 chelate is from carbodithioate (N,Nʹ-dibenzyl-1-carbodithioate (1 and 2) and 4-(2-hydroxyethyl)piperazine-1-carbodithioate (3 and 4)). All complexes exhibited distorted square planar geometry around Pd center owing to the chelate restriction of carbodithioate. The complexes are more potent anticancer (1-4) and antioxidant (3) agents than the standard drugs ((anticancer activity against HepG2: IC50 (µM) =23.39 (1) 65.54 (3) > 62.50 (2) > 39.82 (4)) indicating high selectivity of 1 and 3 towards cancer cells. Anticancer activities were found to depend on the molecular stability and axial protection offered by organophosphine of the complexes.

中文翻译：

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新型杂配钯（II）碳二硫代钯的结构化学和抗癌活性

摘要 合成了四种含有 PdClPS2 配位球的新型有效抗癌钯 (II) 配合物，并通过不同的分析技术对其进行了表征。此处，P 是来自有机膦（三苯基膦（1 和 3）和三（对氯苯基）膦（2 和 4））的供体原子，S2 螯合物来自碳二硫酸酯（N,Nʹ-dibenzyl-1-carbodithioate（1 和 2） ) 和 4-(2-羟乙基)piperazine-1-carbodithioate (3 和 4))。由于二硫代碳化物的螯合限制，所有配合物在 Pd 中心周围都表现出扭曲的方形平面几何形状。复合物是比标准药物更有效的抗癌 (1-4) 和抗氧化剂 (3) 剂（（抗 HepG2 的抗癌活性：IC50 (µM) = 23.39 (1) 65.54 (3) > 62.50 (2) > 39.82 (4) )) 表明 1 和 3 对癌细胞的高选择性。