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Primary Lymphangiosarcoma of the Urinary Bladder in a Dog.
Journal of Comparative Pathology ( IF 0.8 ) Pub Date : 2020-08-10 , DOI: 10.1016/j.jcpa.2020.06.014
M Michishita 1 , Y Ishizaki 1 , M Konnai 1 , Y Machida 1 , R Nakahira 1 , H Hatakeyama 2 , H Yoshimura 3 , M Yamamoto 3 , S Soeta 4 , K Ochiai 5 , K Misawa 6 , N Yugeta 6 , D Azakami 7
Affiliation  

Abdominal ultrasonographical and computed tomography examinations of a 12-year-old neutered female toy poodle revealed a protruding mass, approximately 2 cm in diameter, at the apex of the bladder. The mass was firm and haemorrhagic with a homogeneously brownish–yellow cut surface. Microscopically, it was unencapsulated and located in the muscle layer with invasion of the extra-muscular layer. It was composed of spindloid to oval neoplastic cells that formed irregular clefts and diffuse sheets that dissected bundles of collagen. Immunohistochemically, the neoplastic cells were positive for vimentin and lymphatic vessel endothelial hyaluronan receptor 1 antigens, but negative for cytokeratin AE1/AE3, factor VIII-related antigen, CD31, CD34, Prox-1, S100, desmin, α-smooth muscle actin and MyoD1. Negative immunolabelling for laminin antigen supported the absence of evidence of a basal lamina on ultrastructural examination. Based on these findings, this tumour was identified as a lymphangiosarcoma. To the best of our knowledge, this case is the first report of lymphangiosarcoma arising from the bladder in a dog.



中文翻译:

膀胱中的原发性淋巴肉瘤在狗中。

腹部超声检查和计算机断层扫描检查的是一个12岁的绝育的雌性玩具贵宾犬,在膀胱的顶端发现了肿块,直径约2厘米。肿块牢固,出血,切面均黄褐色至黄色。在显微镜下,它没有被封装并且位于肌肉层中,而侵犯了肌肉外层。它由多倍体到卵形的赘生性细胞组成,形成不规则的裂口和弥散的薄片,可解剖胶原束。免疫组织化学分析,肿瘤细胞中波形蛋白和淋巴管内皮透明质酸受体1抗原呈阳性,而细胞角蛋白AE1 / AE3,因子VIII相关抗原,CD31,CD34,Prox-1,S100,结蛋白,α-平滑肌肌动蛋白和MyoD1。层粘连蛋白抗原的阴性免疫标记支持在超微结构检查中缺乏基底层的证据。基于这些发现,该肿瘤被鉴定为淋巴管肉瘤。据我们所知,该病例是犬膀胱中出现淋巴管肉瘤的首例报道。

更新日期:2020-08-11
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