Background

Oxygen (O₂) cost of walking is a physiological marker of walking dysfunction and reflects the amount of O₂ consumed per kilogram of body weight per unit distance walked. The onset of walking dysfunction (i.e., reduced walking speed and shorter stride length) is commonly observed in Parkinson’s disease (PD), even in the early stages of the disease. However, the O₂ cost of walking has not been assessed in persons with PD.

Research question

Does O₂ cost of walking differ between persons with PD and controls matched by age and sex?

Methods

The sample included 31 persons with mild-to-moderate PD (Hoehn and Yahr stages 2–3) and 31 age- and sex-matched controls in this cross-sectional study. O₂ consumption (VO₂) was measured using a portable indirect calorimetry system during a 6-min period of over-ground walking at a normal comfortable speed, and the O₂ cost of walking was calculated based on the ratio of net relative VO₂ (ml kg⁻¹ min⁻¹) and speed (m min⁻¹).

Results

There were no differences in resting VO₂, steady-state VO₂, and over-ground walking speed between persons with PD and controls (p > 0.05). There was a significant difference in the O₂ cost of walking between persons with PD and healthy controls (p < 0.01) such that persons with PD had a higher O₂ cost of walking. The mean(SD) O₂ cost of walking for persons with PD was 0.179 (0.038) ml kg⁻¹ m⁻¹, and the O₂ cost of walking for healthy controls was 0.153 (0.024) ml kg⁻¹ m⁻¹.

Significance

Persons with PD demonstrated a higher O₂ cost of walking compared with controls, and this may reflect worse walking economy in PD. The possibility of worse walking economy under free-living conditions may result in reduced community ambulation and participation.

中文翻译：

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轻度至中度帕金森病患者在地上行走的氧气消耗。

背景

步行的氧气 (O ₂ ) 成本是步行功能障碍的生理标志，反映了每步行单位距离每公斤体重消耗的 O ₂量。步行功能障碍的发作（即步行速度降低和步幅缩短）在帕金森病 (PD) 中很常见，即使在疾病的早期阶段也是如此。然而，尚未在 PD 患者中评估步行的 O ₂成本。

研究问题

PD 患者和按年龄和性别匹配的对照组之间的O ₂步行成本是否不同？

方法

在这项横断面研究中，样本包括 31 名轻度至中度 PD（Hoehn 和 Yahr 阶段 2-3）和 31 名年龄和性别匹配的对照。O ₂消耗量（VO ₂）使用便携式间接量热仪测量，以正常舒适速度在地面步行6分钟，并根据净相对VO ₂的比率计算步行O ₂成本(ml kg ^-1 min ^-1 )和速度(m min ^-1 )。

结果

PD 患者和对照组的静息 VO ₂、稳态 VO ₂和地上行走速度没有差异（p > 0.05）。PD 患者和健康对照者的步行O ₂成本存在显着差异( p < 0.01)，因此 PD 患者的步行O ₂成本较高。PD 患者步行的平均 (SD) O ₂成本为 0.179 (0.038) ml kg ^-1 m ^-1，健康对照的步行O ₂成本为 0.153 (0.024) ml kg ^-1 m ^-1。

意义

与对照组相比，PD 患者的步行O ₂成本更高，这可能反映了 PD 患者的步行经济性较差。在自由生活条件下步行经济恶化的可能性可能导致社区步行和参与减少。