Tooth compartments and associated supportive tissues exhibit significant alterations during aging, leading to their impaired functioning. Aging not only affects the structure and function of dental tissue but also reduces its capacity to maintain physiological homeostasis and the healing process. Decreased cementocyte viability; diminished regenerative potential of stem cells residing in the pulp, alveolar bone and periodontal ligament; and impaired osteogenic and odontogenic differentiation capacity of progenitor cells are among the cellular impacts associated with oral aging. Various physiological and pathological phenomena are regulated by the epigenome, and hence, changes in epigenetic markers due to external stimuli have been reported in aging oral tissues and are considered a possible molecular mechanism underlying dental aging. The role of nutri-epigenetics in aging has emerged as an attractive research area. Thus far, various nutrients and bioactive compounds have been identified to have a modulatory effect on the epigenetic machinery, showing a promising response in dental aging. The human microbiota is another key player in aging and can be a target for anti-aging interventions in dental tissue. Considering the reversible characteristics of epigenetic markers and the potential for environmental factors to manipulate the epigenome, to minimize the deteriorative effects of aging, it is important to evaluate the linkage between external stimuli and their effects in terms of age-related epigenetic modifications.

牙齿隔室和相关的支持组织在衰老过程中表现出明显的变化，导致它们的功能受损。老化不仅会影响牙齿组织的结构和功能，还会降低其维持生理稳态和愈合过程的能力。牙骨质细胞活力降低；牙髓，牙槽骨和牙周膜中干细胞的再生潜能降低；口腔细胞老化的影响包括祖细胞的成骨和成牙分化能力受损。表观基因组调控着各种生理和病理现象，因此，在衰老的口腔组织中已报道了由于外部刺激引起的表观遗传标记的变化，被认为是牙齿衰老的可能分子机制。营养表观遗传学在衰老中的作用已经成为一个有吸引力的研究领域。迄今为止，已经鉴定出各种营养物和生物活性化合物对表观遗传机制具有调节作用，在牙齿老化中显示出有希望的响应。人类微生物群是衰老的另一个关键因素，可以成为牙齿组织抗衰老干预的目标。考虑到表观遗传标记的可逆特性和环境因素操纵表观基因组的潜力，以最大程度地减少衰老的恶化影响，重要的是评估与年龄相关的表观遗传修饰方面的外部刺激及其影响之间的联系。已经鉴定出各种营养物质和生物活性化合物对表观遗传机制具有调节作用，在牙齿老化中显示出有希望的响应。人类微生物群是衰老的另一个关键因素，可以成为牙齿组织抗衰老干预的目标。考虑到表观遗传标记的可逆特性和环境因素操纵表观基因组的潜力，以最大程度地减少衰老的恶化影响，重要的是评估与年龄相关的表观遗传修饰方面的外部刺激及其影响之间的联系。已经鉴定出各种营养物质和生物活性化合物对表观遗传机制具有调节作用，在牙齿老化中显示出有希望的响应。人类微生物群是衰老的另一个关键因素，可以成为牙齿组织抗衰老干预的目标。考虑到表观遗传标记的可逆特性和环境因素操纵表观基因组的潜力，以最大程度地减少衰老的恶化影响，重要的是评估与年龄相关的表观遗传修饰方面的外部刺激及其影响之间的联系。