Inspired by the limitations of nanoparticles in cancer treatment caused by their low therapeutic effects and biotoxicity, biocompatible and photothermal enhanced copper oxide-decorated carbon nanospheres (CuO@CNSs) with doxorubicin hydrochloride (DOX) loading were constructed. CNSs as photothermal agents were synthesized by a hydrothermal reaction. CuO was adsorbed on the surface of CNSs, which improved the photothermal conversion efficiency due to the electron transitions between C-2p and Cu-3d. In addition, CuO would release Cu²⁺ ions in the tumor microenvironment, which could produce hydroxyl radical (·OH) to induce cancer cells apoptosis via Haber-Weiss and Fenton-like reactions. DOX as a chemotherapeutic agent was located on the surface of CuO@CNSs by electrostatic adsorption and released quickly in the tumor microenvironment to kill cancer cells. The CuO@CNSs-DOX nanoplatforms realized the combination therapy of photothermal therapy (PTT), chemodynamic therapy (CDT), and chemotherapy (CT), which have strong potential for cancer treatment.

受纳米粒子因其低治疗效果和生物毒性而在癌症治疗中的局限性启发，构建了负载有阿霉素的生物相容性和光热增强型氧化铜修饰的碳纳米球（CuO @ CNSs）。通过水热反应合成了CNSs作为光热剂。CuO吸附在CNS的表面，由于C-2p和Cu-3d之间的电子跃迁而提高了光热转换效率。此外，CuO会在肿瘤微环境中释放Cu ²⁺离子，从而产生羟基自由基（·OH）从而通过以下方式诱导癌细胞凋亡Haber-Weiss和Fenton样的反应。作为化学治疗剂的DOX通过静电吸附位于CuO @ CNSs的表面，并在肿瘤微环境中迅速释放以杀死癌细胞。CuO @ CNSs-DOX纳米平台实现了光热疗法（PTT），化学动力疗法（CDT）和化学疗法（CT）的联合疗法，在癌症治疗方面具有强大的潜力。