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Botany, traditional use, phytochemistry, pharmacology and toxicology of Sigesbeckiae Herba ( Xixiancao ): a review
Phytochemistry Reviews ( IF 7.7 ) Pub Date : 2020-08-11 , DOI: 10.1007/s11101-020-09714-4
Hong Xun Tao , Guan Ding Zhao , Ke Gang Linghu , Wei Xiong , Wei Sang , Yu Peng , Yitao Wang , Hua Yu

Sigesbeckiae Herba is a traditional Chinese herbal medicine and has been used for inflammatory diseases with a long history. The current official plant origins of Sigesbeckiae Herba include Sigesbeckia orientalis L. (SO), S. pubescens Markino (SP) and S. glabrescens Markino (SG). In this work, a systemic review about the scientific work for medicinal Sigesbeckiae Herba regarding their botanical descriptions, reported bioactive components, pharmacological activities and toxicities was performed. The results indicate that a total of 251 compounds including flavonoids, diterpenoids, sesquiterpenoids, triterpenoids, and sterols have been isolated from Sigesbeckia plants and reported to be characteristically distributed in SO, SP and SG. The extracts and pure compounds derived from Sigesbeckiae Herba are reported to present various pharmacological activities including anti-inflammation, immunomodulation, anti-cancer, and others. Although no significant side-effects and toxicities for Sigesbeckiae Herba have been reported in clinics, the potential pulmonary toxicity for the water extracts of SH are reported in experimental animals. In conclusion, Sigesbeckiae Herba is a valuable Chinese herbal medicine and has been investigated to present multiple pharmacological activities. The main pharmacological investigations support its traditional use for treating chronic inflammatory diseases. The available literature shows that much of the activity of Sigesbeckiae Herba can be attributed to diterpenoids, sesquiterpenoids and flavonoids. However, further investigations on the molecular mechanisms to pharmacological activities and the potential toxicities is recommended. Moreover, further investigations on the comparative comprehension among the three medicinal Sigesbeckia plants (SO, SP and SG) both in chemistry and pharmacology are also recommended for their precise applications in clinics.



中文翻译:

七仙草的植物学,传统用途,植物化学,药理毒理学:综述

百日草(Sigesbeckiae Herba)是一种传统中草药,已被用于治疗炎症的悠久历史。Sigesbeckiae草的当前官方植物来源包括豨莶L.(SO),S.毛Markino(SP)和S.莶Markino(SG)。在这项工作中,对药用Sigesbeckiae Herba的植物学描述,报道的生物活性成分,药理活性和毒性进行了科学综述。结果表明,已从ges草植物中分离出总共251种化合物,包括黄酮类,二萜类,倍半萜类,三萜类和固醇,并据报道在SO,SP和SG中具有特征性分布。据报道,提取自西格斯菊的提取物和纯化合物具有多种药理活性,包括抗炎,免疫调节,抗癌等。尽管在临床上没有报道过针对Sigesbeckiae Herba的明显副作用和毒性,在实验动物中报道了SH水提取物的潜在肺毒性。综上所述,Si药是一种有价值的中草药,经过研究可表现出多种药理活性。主要药理研究支持其在治疗慢性炎性疾病中的传统用途。现有文献表明,虎杖的许多活性可归因于二萜,倍半萜和黄酮。但是,建议进一步研究药理活性的分子机制和潜在的毒性。此外,还对三种药用Sigesbeckia植物(SO,

更新日期:2020-08-11
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