Compared with traditional drug delivery methods, transdermal drug delivery has many advantages in avoiding the side effects in gastrointestinal tract, reducing the fluctuations in drug concentration, and improving patients’ compliance. Among them, electrically controlled drug delivery is a promising solution. This work presents a wireless, battery-free and wearable device with electrically controlled drug delivery capability. The electronic component of the device is a flexible circuit board with a temperature sensor and a near-field communication module. With the help of smartphone, the device could wirelessly obtain energy and implement data transmission. The drug delivery component is a paper-based electrode modified with polypyrrole, in which non-steroidal anti-inflammatory drug sodium salicylate was encapsulated. The applied potential for electrically controlled drug delivery was more negative than −0.6 V. The drug release dose and release rates could be controlled by applying potentials with different amplitudes and durations through this device. It provided a minimalized wearable transdermal drug delivery platform for monitoring diseases such as gout. This wearable device shows promising potential in develop closed-loop drug delivery and monitoring systems for the treatment of various diseases.

中文翻译：

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无线，无需电池且可穿戴的用于电控药物输送的设备：通过智能手机上的近场通信从双层聚吡咯释放出的水杨酸钠。

与传统的药物输送方法相比，经皮药物输送在避免胃肠道副作用，减少药物浓度波动以及提高患者依从性方面具有许多优势。其中，电控药物输送是一种有前途的解决方案。这项工作提出了一种具有电控药物输送功能的无线，无电池且可穿戴的设备。该设备的电子组件是具有温度传感器和近场通信模块的柔性电路板。借助智能手机，该设备可以无线获取能量并实现数据传输。药物输送组件是用聚吡咯修饰的纸基电极，其中包裹了非甾体类抗炎药水杨酸钠。电控药物输送所施加的电位比-0.6 V负得多。可以通过该装置施加不同幅度和持续时间的电位来控制药物释放剂量和释放速率。它提供了一个最小化的可穿戴透皮给药平台，用于监测痛风等疾病。这种可穿戴设备在开发用于治疗各种疾病的闭环药物输送和监测系统方面显示出有希望的潜力。