Fibroblast growth factor 21 (FGF21) and β-Klotho (KLB) play an important role in preventing and treating overweight and obesity. However, it is unclear what conditions promote FGF21 and KLB expression in different tissues. Therefore, we studied expression of FGF21 and KLB with respect to two exercise regimes: moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) (two popular strategies in weight loss). Mice were randomly divided into three groups (n = 8 per group): MICT, HIIT, and sedentary lifestyle (SED). All mice were fed a high-fat diet (HFD) for 12 weeks to induce obesity. The exercise was performed on a motorized treadmill for another eight weeks and the diet continued in each group. We found that both MICT and HIIT had positive effects on the loss of HFD-induced body weight increase and serum FGF21 levels. HIIT promoted decrease of the body weight and serum triglyceride (TG) levels, while MICT was more effective at enhancing FGF21 and KLB expression in the liver, brown adipose tissue (BAT), and muscle at the mRNA and protein levels.

中文翻译：

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中等强度持续训练可改善肥胖小鼠的 FGF21 和 KLB 表达

成纤维细胞生长因子 21 (FGF21) 和 β-Klotho (KLB) 在​​预防和治疗超重和肥胖方面发挥着重要作用。然而，尚不清楚是什么条件促进了不同组织中 FGF21 和 KLB 的表达。因此，我们研究了 FGF21 和 KLB 在两种运动方式下的表达：中等强度持续训练 (MICT) 和高强度间歇训练 (HIIT)（两种流行的减肥策略）。小鼠被随机分为三组（每组 n = 8）：MICT、HIIT 和久坐生活方式（SED）。所有小鼠都喂食高脂肪饮食 (HFD) 12 周以诱导肥胖。该运动在电动跑步机上进行了另外八周，每组继续饮食。我们发现 MICT 和 HIIT 对 HFD 诱导的体重增加和血清 FGF21 水平的减少都有积极影响。