当前位置: X-MOL 学术Biochemistry Moscow › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Role of NUDIX Hydrolases in NAD and ADP-Ribose Metabolism in Mammals
Biochemistry (Moscow) ( IF 2.8 ) Pub Date : 2020-08-01 , DOI: 10.1134/s0006297920080040
V. A. Kulikova , A. A. Nikiforov

Proteins of the NUDIX hydrolase (NUDT) superfamily that cleave organic pyrophosphates are found in all classes of organisms, from archaea and bacteria to higher eukaryotes. In mammals, NUDTs exhibit a wide range of functions and are characterized by different substrate specificity and intracellular localization. They control the concentration of various metabolites in the cell, including key regulatory molecules such as nicotinamide adenine dinucleotide (NAD), ADP-ribose, and their derivatives. In this review, we discuss the role of NUDT proteins in the metabolism of NAD and ADP-ribose in human and animal cells.

中文翻译:

NUDIX 水解酶在哺乳动物 NAD 和 ADP-核糖代谢中的作用

切割有机焦磷酸盐的 NUDIX 水解酶 (NUDT) 超家族的蛋白质存在于所有类别的生物体中,从古细菌和细菌到高等真核生物。在哺乳动物中,NUDTs 表现出广泛的功能,并以不同的底物特异性和细胞内定位为特征。它们控制细胞中各种代谢物的浓度,包括关键调节分子,如烟酰胺腺嘌呤二核苷酸 (NAD)、ADP-核糖及其衍生物。在这篇综述中,我们讨论了 NUDT 蛋白在人类和动物细胞中 NAD 和 ADP 核糖代谢中的作用。
更新日期:2020-08-01
down
wechat
bug