Endogenous clocks enable organisms to adapt their physiology and behavior to daily variation in environmental conditions. Metabolic processes in cyanobacteria to humans are effected by the circadian clock, and its dysregulation causes metabolic disorders. In mouse and Drosophila were shown that the circadian clock directs translation of factors involved in ribosome biogenesis and synchronizes protein synthesis. However, the role of clocks in Drosophila neurogenesis and the potential impact of clock impairment on neural circuit formation and function is less understood. Here we demonstrate that light stimuli or circadian clock causes a defect in neural stem cell growth and proliferation accompanied by reduced nucleolar size. Further, we define that light and clock independently affect the InR/TOR growth regulatory pathway due to the effect on regulators of protein biosynthesis. Altogether, these data suggest that alterations in growth regulatory pathways induced by light and clock are associated with impaired neural development.

中文翻译：

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光刺激和昼夜节律影响果蝇的神经发育。

内源时钟使生物能够适应其生理和行为以适应环境条件的日常变化。蓝藻对人类的代谢过程受昼夜节律影响，其失调会引起代谢紊乱。在小鼠和果蝇中，昼夜节律时钟指示核糖体生物发生相关因子的翻译并同步蛋白质合成。然而，人们对钟在果蝇神经发生中的作用以及钟损害对神经回路形成和功能的潜在影响知之甚少。在这里，我们证明光刺激或昼夜节律引起神经干细胞生长和增殖的缺陷，伴随着核仁大小的减少。进一步，我们定义由于对蛋白质生物合成调节剂的影响，光和时钟独立地影响InR / TOR生长调节途径。总之，这些数据表明，光和时钟诱导的生长调节途径的改变与神经发育受损有关。