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Common Genetic Influences on Age at Pubertal Voice Change and BMI in Male Twins
Twin Research and Human Genetics ( IF 0.9 ) Pub Date : 2020-08-10 , DOI: 10.1017/thg.2020.65 Yoon-Mi Hur 1
Twin Research and Human Genetics ( IF 0.9 ) Pub Date : 2020-08-10 , DOI: 10.1017/thg.2020.65 Yoon-Mi Hur 1
Affiliation
The present study aimed to explore secular trends in age at voice change (AVC), estimate heritability of AVC and investigate to what extent common genes influence the association between AVC and body mass index (BMI) in South Korean males. The sample of 955 male twins consisted of 241 pairs and 118 co-twin missing monozygotic (MZ) twins, 82 pairs and 50 co-twin missing dizygotic (DZ) twins and 141 male members of opposite-sex DZ twins who participated in telephone surveys in the South Korean Twin Registry. AVC was asked of twins during the surveys. The mean (SD ) age of the sample was 18.92 (2.42) years (range: 16.00–29.25 years). The birth years of the twins were divided into two groups (1988–1993, 1994–2001). Kaplan–Meyer survival analyses were conducted to compute the mean age of AVC in the total sample as well as to test mean differences between the two birth cohorts. Maximum likelihood twin correlations and univariate and bivariate model-fitting analyses were performed. The mean AVC in the total sample was 14.19 (95% CI [14.09, 14.29]) years. The mean AVC significantly declined from 14.38 to 14.02 years from 1988 to 2001, confirming downward trends in AVC in recent years. Heritability for AVC was .59 (95% CI [.50, .67]), which was within the range reported in most Western twin studies. Although the phenotypic correlation between AVC and BMI was modest (r = −.14; 95% CI [−.07, −.21]), it was entirely mediated by common genes, similar to what has been found in females in prior twin studies. In conclusion, the present twin study underscores the importance of genetic influences on pubertal timing and its association with BMI in South Korean males.
中文翻译:
男性双胞胎青春期声音变化和 BMI 年龄的常见遗传影响
本研究旨在探索声音变化年龄 (AVC) 的长期趋势,估计 AVC 的遗传力,并调查常见基因在多大程度上影响韩国男性 AVC 与体重指数 (BMI) 之间的关联。955 对男性双胞胎样本包括 241 对和 118 对同卵双胞胎缺失的单卵双胞胎,82 对和 50 对同卵双胞胎缺失的双卵双胞胎和 141 名异性 DZ 双胞胎的男性成员参与电话调查在韩国双胞胎登记处。在调查期间,AVC 被问及双胞胎。均值 (标清 ) 样本年龄为 18.92 (2.42) 岁(范围:16.00–29.25 岁)。双胞胎的出生年份分为两组(1988-1993、1994-2001)。进行 Kaplan-Meyer 生存分析以计算总样本中 AVC 的平均年龄,并测试两个出生队列之间的平均差异。进行了最大似然双相关以及单变量和双变量模型拟合分析。总样本的平均 AVC 为 14.19 (95% CI [14.09, 14.29]) 年。从 1988 年到 2001 年,平均 AVC 从 14.38 年显着下降到 14.02 年,证实了近年来 AVC 的下降趋势。AVC 的遗传率为 0.59 (95% CI [.50, .67]),这在大多数西方双胞胎研究报告的范围内。尽管 AVC 和 BMI 之间的表型相关性不大(r = -.14; 95% CI [-.07, -.21]),它完全由共同基因介导,类似于在先前双胞胎研究中发现的女性。总之,目前的双胞胎研究强调了遗传影响对青春期时机的重要性及其与韩国男性 BMI 的关系。
更新日期:2020-08-10
中文翻译:
男性双胞胎青春期声音变化和 BMI 年龄的常见遗传影响
本研究旨在探索声音变化年龄 (AVC) 的长期趋势,估计 AVC 的遗传力,并调查常见基因在多大程度上影响韩国男性 AVC 与体重指数 (BMI) 之间的关联。955 对男性双胞胎样本包括 241 对和 118 对同卵双胞胎缺失的单卵双胞胎,82 对和 50 对同卵双胞胎缺失的双卵双胞胎和 141 名异性 DZ 双胞胎的男性成员参与电话调查在韩国双胞胎登记处。在调查期间,AVC 被问及双胞胎。均值 (