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Biotechnological potential of Beauveria bassiana as a source of novel biocatalysts and metabolites.
Critical Reviews in Biotechnology ( IF 9 ) Pub Date : 2020-08-10 , DOI: 10.1080/07388551.2020.1805403
Ayodeji Amobonye 1 , Prashant Bhagwat 1 , Ashok Pandey 2 , Suren Singh 1 , Santhosh Pillai 1
Affiliation  

Beauveria bassiana though widely perceived as an entomopathogenic fungus has also been found in nature to be endophytic. As entomopathogens, the life cycle of different B. bassiana strains are organized and adapted as pathogens to their invertebrate hosts while as endophytes they maintain a symbiotic relationship with their plant hosts. To fulfill these aforementioned ecological roles, this fungus secretes an array of enzymes as well as secondary metabolites, which all have significant biological roles. Basically, chitinases, lipases and proteases are considered to be the most important of all the enzymes produced by B. bassiana. However, studies have also shown their ability to produce other vital enzymes which include amylase, asparaginase, cellulase, galactosidase etc. Previous reports on this filamentous fungus have laid more emphasis on its entomopathogenicity, its endophytism and its highly acclaimed application in the biological control of pests. This review, however, is the first to fully assess the enzyme-secreting potential of this entomopathogenic fungus and its use as a novel source of several industrial biocatalysts and other important biochemicals. This article highlights the inherent properties of the fungus to degrade various biopolymers as well as its relative safety for human use. Some of the important factors have raised the possibilities of exploitation for industrial production and as safe hosts for gene expression.



中文翻译:

球孢白僵菌作为新型生物催化剂和代谢产物的生物技术潜力。

球孢白僵菌虽然被广泛认为是昆虫病原性真菌,但在自然界中也发现是内生的。作为昆虫病原体,不同芽孢杆菌菌株的生命周期经过组织,可以作为无脊椎动物宿主的病原体,而作为内生菌,它们与植物宿主保持共生关系。为了履行上述生态作用,该真菌分泌了一系列酶和次生代谢物,它们均具有重要的生物学作用。基本上,几丁质酶,脂肪酶和蛋白酶被认为是球孢杆菌产生的所有酶中最重要的。但是,研究也表明它们具有产生其他重要酶的能力,包括淀粉酶,天冬酰胺酶,纤维素酶,半乳糖苷酶等。关于这种丝状真菌的先前报道已将重点更多地放在其昆虫致病性,内生性及其在对虾的生物防治中广受赞誉的应用中。害虫。但是,这项综述是首次全面评估这种昆虫病原真菌的酶分泌潜力,并将其用作几种工业生物催化剂和其他重要生物化学物质的新来源。本文着重介绍了降解各种生物聚合物的真菌的固有特性及其对人类使用的相对安全性。一些重要因素提高了工业生产利用和基因表达安全宿主的可能性。

更新日期:2020-09-14
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