Abstract Withania frutescens (W. frutescens) is a medicinal plant that is largely used in the Morrocan pharmacopeia for disease treatment. This work was conducted to investigate the chemical characterization, analgesic, anti-inflammatory, and healing activities of W. frutescens. The chemical characterization of W. frutescens extract was done using HPLC; the anti-inflammatory test was performed with doses 300, 400 and 450 mg/kg, and the healing activity was assessed using two creams (extract 5% and extract 10%). Phytochemical analysis revealed the presence of phenolic compounds. The results of the anti-inflammatory test were more pronounced when compared with the reference drug with a maximum inhibition percentage of 82.20% ± 8.69 obtained at the dose of 450 mg/kg. Local application of 10% plant cream induced 80.17% ± 7.89 of inflammation inhibition when compared with the indomethacin drug 92.33% ± 11.27. The studied plant extract showed a promising healing activity with the following percentage: 99.03% ± 0.76 (extract 10%), 98.61% ± 1.91 (extract 5%), and 57.43% ± 2.97 (control); meanwhile, the value reached to 100% ± 0.02 for the drug that was used as a reference within the first 2 weeks. The plant studied in this work would be a promising source for conceptualizing effective drugs against inflammatory diseases.

中文翻译：

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Withania frutescens：化学特性、镇痛、抗炎和愈合活性

摘要 Withania frutescens (W. frutescens) 是一种药用植物，在摩洛哥药典中广泛用于疾病治疗。进行这项工作是为了研究 W. frutescens 的化学特性、镇痛、抗炎和愈合活性。W. frutescens 提取物的化学表征使用 HPLC 进行；以 300、400 和 450 mg/kg 的剂量进行抗炎试验，并使用两种乳膏（提取物 5% 和提取物 10%）评估愈合活性。植物化学分析表明存在酚类化合物。与参比药物相比，抗炎试验的结果更为显着，在 450 mg/kg 剂量下获得的最大抑制率为 82.20%±8.69。局部施用 10% 植物乳膏诱导 80.17% ± 7。89与消炎痛药相比，炎症抑制率为92.33%±11.27。所研究的植物提取物显示出有希望的愈合活性，百分比如下：99.03% ± 0.76（提取物 10%）、98.61% ± 1.91（提取物 5%）和 57.43% ± 2.97（对照）；同时，在前 2 周内用作参考的药物的值达到 100% ± 0.02。在这项工作中研究的植物将成为概念化针对炎症性疾病的有效药物的有希望的来源。