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Role of rs6265 BDNF polymorphisms and post-stroke dysphagia recovery-A prospective cohort study.
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-08-09 , DOI: 10.1111/nmo.13953
Hyun Mi Oh 1, 2 , Tae-Woo Kim 1, 2 , Hae-Yeon Park 3 , Youngkook Kim 4 , Geun-Young Park 5 , Sun Im 5
Affiliation  

Previous studies suggest that specific genes may predispose some to increased risk of dysphagia in the geriatric population, but whether these genes may affect swallowing recovery after a stroke is unknown. This study investigated whether single‐nucleotide polymorphisms (SNP) of the brain‐derived neurotrophic factor (BDNF), catechol‐O‐methyl transferase, apolipoprotein E, interleukin‐1 receptor antagonist, and dopamine, which have been linked to swallowing, could adversely affect the prognosis of post‐stroke dysphagia.

中文翻译:

rs6265 BDNF 多态性和卒中后吞咽困难恢复的作用——一项前瞻性队列研究。

先前的研究表明,特定基因可能会增加老年人吞咽困难的风险,但这些基因是否会影响中风后的吞咽恢复尚不清楚。本研究调查了与吞咽有关的脑源性神经营养因子 (BDNF)、儿茶酚-O-甲基转移酶、载脂蛋白 E、白细胞介素-1 受体拮抗剂和多巴胺的单核苷酸多态性 (SNP) 是否会对吞咽产生不利影响。影响脑卒中后吞咽困难的预后。
更新日期:2020-08-09
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