Carbon monoxide (CO) has emerged as a potential therapeutic agent for the treatment of many diseases. However, the therapeutic outcome is highly dependent on the dosages and administration sites. Hence, there is mounting interest in the development of CO‐releasing materials to accomplish site‐specific and dose‐controlled delivery of CO. Herein, a micellar nanoparticle platform for the photo‐mediated release of CO by using amphiphilic triblock copolymers bearing CO‐releasing moieties of 3‐hydroxylflavone (3‐HF) derivatives within the middle blocks is developed. These micelles are relatively stable without CO leakage but undergo visible light‐mediated CO release and simultaneous main chain scission. Moreover, these micellar nanoparticles are cytocompatible regardless of light irradiation, which shows unique anti‐inflammatory performance only after light irradiation as a result of photo‐triggered CO release. This work may represent the first example of main‐chain degradable micellar nanocarriers with controlled CO‐releasing performance for potential anti‐inflammatory applications.

中文翻译：

---

能够在可见光照射下释放一氧化碳的光降解胶束。

一氧化碳（CO）已经成为治疗多种疾病的潜在治疗剂。但是，治疗结果高度依赖于剂量和给药部位。因此，人们对开发CO释放材料以实现特定位置和剂量控制的CO的开发越来越感兴趣。在这里，通过使用带有CO释放的两亲三嵌段共聚物，光胶释放CO的胶束纳米颗粒平台开发了中间嵌段内的3-羟基黄酮（3-HF）衍生物部分。这些胶束相对稳定，没有CO泄漏，但会经历可见光介导的CO释放和同时主链断裂。而且，这些胶束纳米颗粒与细胞无关，无论光照如何，由于光触发的CO释放，仅在光照射后才显示出独特的抗炎性能。这项工作可能代表了具有可控CO释放性能且可用于潜在抗炎应用的主链可降解胶束纳米载体的第一个例子。