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Metagenomics analysis of intestinal flora modulatory effect of green tea polyphenols by a circadian rhythm dysfunction mouse model.
Journal of Food Biochemistry ( IF 4 ) Pub Date : 2020-08-10 , DOI: 10.1111/jfbc.13430 Li Zhang 1 , Ruonan Yan 2 , Zufang Wu 2
Journal of Food Biochemistry ( IF 4 ) Pub Date : 2020-08-10 , DOI: 10.1111/jfbc.13430 Li Zhang 1 , Ruonan Yan 2 , Zufang Wu 2
Affiliation
The present study investigated the regulatory mechanism of green tea polyphenols (GTP) on the circadian rhythm of gut flora. The administration of GTP mitigated the variations in the serum and liver level of constant dark (CD)‐induced circadian rhythm disorder mouse model. For the gut microbial population, GTP promoted the relative abundance of Bacteroidetes while inhibited Firmicutes. Furthermore, KEGG pathways of biosynthesis of amino acids, two‐component system and ATP‐binding cassette translocators enriched the most differentially expressed genes after GTP interference. It indicated GTP may prevent CD‐induced circadian rhythm disorder, which has an enormous potential to be utilized as prebiotic‐like ingredients in food industry.
中文翻译:
昼夜节律紊乱小鼠模型对绿茶多酚对肠道菌群调节作用的元基因组学分析。
本研究探讨了绿茶多酚(GTP)对肠道菌群昼夜节律的调节机制。GTP的使用减轻了恒定黑暗(CD)引起的昼夜节律障碍小鼠模型的血清和肝脏水平的变化。对于肠道微生物种群,GTP促进了拟杆菌的相对丰度,而抑制了纤毛虫。此外,在GTP干扰后,氨基酸,两组分系统和ATP结合盒式转运蛋白的生物合成的KEGG途径丰富了差异最大的表达基因。这表明GTP可以预防CD引起的昼夜节律紊乱,这在食品工业中具有作为益生元样成分的巨大潜力。
更新日期:2020-10-11
中文翻译:
昼夜节律紊乱小鼠模型对绿茶多酚对肠道菌群调节作用的元基因组学分析。
本研究探讨了绿茶多酚(GTP)对肠道菌群昼夜节律的调节机制。GTP的使用减轻了恒定黑暗(CD)引起的昼夜节律障碍小鼠模型的血清和肝脏水平的变化。对于肠道微生物种群,GTP促进了拟杆菌的相对丰度,而抑制了纤毛虫。此外,在GTP干扰后,氨基酸,两组分系统和ATP结合盒式转运蛋白的生物合成的KEGG途径丰富了差异最大的表达基因。这表明GTP可以预防CD引起的昼夜节律紊乱,这在食品工业中具有作为益生元样成分的巨大潜力。