Hydroxyapatite (HA) is a well‐known regenerative biomaterial. However, the slow degradation rate of HA is still an obstacle in clinical applications. In this study, we concentrated on investigating the degradation behavior of the calcium‐rich HA foams, which had a demonstrated effect on blood differentiation in previous studies. The HA foams were processed by an emulsion method and were infiltrated with calcium nitrate to create a calcium carbonate second phase, heterogeneously distributed on and under the surface of the foam. During the 28‐day solubility test, the calcium carbonate phase contributed to enhanced Ca²⁺ ion release into the saline compared to phase pure HA foams. Both types of foams were biocompatible as demonstrated by human endothelial cell culture on their surface. The release of calcium ions, the degradation behavior, and the endothelial cell differentiation behavior suggest this biphasic ceramic is a candidate for bone marrow in vitro culture and a possible bone substitute material.

中文翻译：

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富钙羟基磷灰石泡沫体外降解行为

羟基磷灰石（HA）是一种众所周知的再生生物材料。然而，HA缓慢的降解速度仍然是临床应用中的障碍。在这项研究中，我们专注于研究富含钙的 HA 泡沫的降解行为，这在之前的研究中对血液分化有明显的影响。HA 泡沫通过乳液方法处理，并用硝酸钙渗透以产生碳酸钙第二相，在泡沫表面上和下不均匀分布。在 28 天的溶解度测试中，碳酸钙相有助于增强 Ca ²⁺与纯相 HA 泡沫相比，离子释放到盐水中。两种类型的泡沫都具有生物相容性，正如其表面的人类内皮细胞培养所证明的那样。钙离子的释放、降解行为和内皮细胞分化行为表明这种双相陶瓷是骨髓体外培养的候选材料和可能的骨替代材料。