A luminescent and dual-stimuli-responsive nanocomposite based on mesoporous silica, poly (N-isopropylacrylamide)-chitosan and decatungstoeuropate was prepared. To fabricate the nanocomposite, the mesoporous silica nanoparticles were coated with thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan and the luminescent decatungstoeuropate particles were grafted onto copolymers. The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX). The research indicated that the releases of DOX were thermo/pH dependent and high temperatures/acidic conditions were favorable for the fast release of drug. In vitro cytotoxicity tests revealed that the drug delivery carrier displayed excellent biocompatible and the composites loaded with DOX showed significant suppression effect on HeLa cells. Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.

制备了基于介孔二氧化硅，聚（N-异丙基丙烯酰胺）-壳聚糖和癸二硬脂酸酯的发光和双刺激响应纳米复合材料。为了制造纳米复合材料，用热/ pH双响应聚（N-异丙基丙烯酰胺）-壳聚糖包被介孔二氧化硅纳米粒子，然后将发光的反二十二碳六烯酸酯粒子接枝到共聚物上。设计的纳米载体可以表现出良好的红色发光以及明显的热/ pH刺激响应特性，可以用作抗癌药物阿霉素（DOX）的加载和释放的药物储存库。研究表明，DOX的释放与温度/ pH有关，高温/酸性条件有利于药物的快速释放。体外细胞毒性测试表明，药物输送载体表现出优异的生物相容性，负载有DOX的复合材料对HeLa细胞具有明显的抑制作用。发光光谱表明，含有十碳二硬脂酸酯的复合物在各种温度和pH值下均显示出精细的红色发光，可以用作医学领域的潜在标记材料。