A fully functional placenta is critical for a successful pregnancy. In this issue of Developmental Cell, Singh et al. reveal that excessive placental DNA damage in murine models for Cornelia de Lange syndrome results in an inefficient and senescent placenta that impairs embryonic development.

中文翻译：

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保持冷静，胎盘会继续。

功能齐全的胎盘对于成功怀孕至关重要。在本期《发育细胞》中，Singh等人。揭示在Cornelia de Lange综合征的鼠模型中过度的胎盘DNA损伤会导致低效和衰老的胎盘，从而损害胚胎发育。