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Spinal interleukin-6 contributes to central sensitisation and persistent pain hypersensitivity in a model of juvenile idiopathic arthritis
Brain, Behavior, and Immunity ( IF 15.1 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.bbi.2020.08.004
Charlie H T Kwok 1 , Annastazia E Learoyd 2 , Julia Canet-Pons 1 , Tuan Trang 1 , Maria Fitzgerald 2
Affiliation  

Highlights • Duration of joint inflammatory pain behaviour is prolonged in juvenile rats compared to adult rats.• Spinal neuron hyperexcitability mirror pain behaviours of both juvenile and adult rats.• Persistent upregulation of interleukin-6 uniquely observed in spinal cord of juvenile rats.• Inhibition of spinal interleukin-6 activity rescued pain and normalised spinal neuron activity.

中文翻译:

脊髓白细胞介素 6 有助于幼年特发性关节炎模型的中枢敏化和持续性疼痛超敏反应

亮点 • 与成年大鼠相比,幼年大鼠的关节炎性疼痛行为持续时间延长。• 脊髓神经元过度兴奋反映了幼年和成年大鼠的疼痛行为。• 在幼年大鼠脊髓中观察到独特的白细胞介素 6 持续上调。• 抑制脊髓白细胞介素 6 活性的降低可缓解疼痛并使脊髓神经元活动正常化。
更新日期:2020-11-01
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