Abstract

Perimidines are versatile scaffolds and a fascinating class of N-heterocycles that have evolved significantly in recent years due to their immense applications in life sciences, medical sciences, and industrial chemistry. Their ability of molecular interaction with different proteins, complex formation with metals, and distinct behavior in various ranges of light makes them more appealing and challenging for future scientists. Various novel technologies have been developed for the selective synthesis of perimidines and their conjugated derivatives. These methods extend to the preparation of different bioactive and industrially applicable molecules. This review aims to present the most recent advancements in perimidine synthesis under varied conditions like MW radiation, ultrasound, and grinding using different catalysts such as ionic liquids, acid, metal, and nanocatalyst and also under green environments like catalyst and solvent-free synthesis. The applications of perimidine derivatives in drug discovery, polymer chemistry, photo sensors, dye industries, and catalytic activity in organic synthesis are discussed in this survey. This article is expected to be a systematic, authoritative, and critical review on the chemistry of perimidines that compiles most of the state-of-art innovation in this area.

Graphic Abstract

中文翻译：

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嘧啶类化合物的合成及其应用的最新进展。

摘要

Perimidines 是多功能支架和迷人的N类-近年来由于在生命科学、医学和工业化学中的巨大应用而发生了显着变化的杂环化合物。它们与不同蛋白质的分子相互作用、与金属形成复合物的能力以及在各种光范围内的独特行为使它们对未来的科学家更具吸引力和挑战性。已经开发了多种用于选择性合成哌啶及其共轭衍生物的新技术。这些方法扩展到制备不同的生物活性和工业应用分子。本综述旨在介绍在不同条件下，如 MW 辐射、超声波和使用不同催化剂（如离子液体、酸、金属、和纳米催化剂，以及在催化剂和无溶剂合成等绿色环境下。本综述讨论了哌啶衍生物在药物发现、聚合物化学、光传感器、染料工业和有机合成催化活性中的应用。这篇文章有望成为关于哌啶化学的系统、权威和批判性的综述，汇集了该领域的大部分最新创新成果。

图形摘要