The emergence of plasmid-mediated tet(X3)/tet(X4) genes is threatening the role of tigecycline as a last-resort antibiotic to treat clinical infections caused by XDR bacteria. Considering the possible public health threat posed by tet(X) and its variants [which we collectively call ‘tet(X) genes’ in this study], global monitoring and surveillance are urgently required.

中文翻译：

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替加环素抗性基因的tet（X）家族的全球分布和扩散的初步视图。

质粒介导的tet（X3）/ tet（X4）基因的出现正威胁着替加环素作为治疗XDR细菌引起的临床感染的最后手段的作用。考虑到tet（X）及其变体（在本研究中我们统称为“ tet（X）基因”）可能构成的公共健康威胁，因此迫切需要进行全局监视和监视。