ABSTRACT

Background

Osteoarthritis (OA) pain is a health care highly demanding and costing condition.

Objective

To estimate disease burden on health care in OA in Spain, determining whether burden differs by pain severity and usual analgesic treatment.

Methods

A cross-sectional design using the 2017-Spanish-National-Health-Survey was used to abstract data of 5,234 adult patients (women 70.8%; 69.9 years) with a self-reported physician OA diagnosis. Patients were assembled according to pain severity (no/mild, moderate, severe) and use of usual analgesia (treated [66.5%]/untreated). Healthcare resource utilization (HRU) and corresponding costs were expressed Per-Patient-Per-Year (PPPY) and adjusted for covariates.

Results

Average (SD) healthcare cost was €2,274 (5,461) PPPY, with costs linked to outpatient medical visits being the major driver; ~43%. Adjusted PPPY medical visits, days of hospitalization, other healthcare visits, and corresponding costs were significantly higher in severe pain OA patients, compared to moderate or mild/no pain regardless of being currently treated with usual analgesics or not (p < 0.001). Treated OA patients showed higher HRU and costs than untreated patients.

Conclusions

Severity of pain was the main driver of HRU and costs in OA patients from a nationwide representative survey in Spain. These findings seem to be more consistent in treated versus not treated patients with usual analgesics.

中文翻译：

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症状性骨关节炎患者疼痛严重程度和常规镇痛治疗对医疗保健的疾病负担：西班牙全国健康调查

摘要

背景

骨关节炎 (OA) 疼痛是一种医疗保健要求高且成本高昂的疾病。

客观的

为了估计西班牙 OA 医疗保健的疾病负担，确定负担是否因疼痛严重程度和常规镇痛治疗而异。

方法

使用 2017-Spanish-National-Health-Survey 的横断面设计用于提取 5,234 名成年患者（女性 70.8%；69.9 岁）的数据，这些患者自我报告医生 OA 诊断。根据疼痛严重程度（无/轻度、中度、重度）和使用常规镇痛剂（治疗 [66.5%]/未治疗）对患者进行分组。医疗资源利用率 (HRU) 和相应的成本以每位患者每年 (PPPY) 表示，并针对协变量进行了调整。

结果

平均 (SD) 医疗保健费用为 2,274 欧元 (5,461) PPPY，其中与门诊就诊相关的费用是主要驱动力；〜43％。与中度或轻度/无疼痛相比，无论目前是否使用常规镇痛剂治疗，重度疼痛 OA 患者的调整后 PPPY 就诊、住院天数、其他医疗就诊和相应费用显着更高（p < 0.001）。接受治疗的 OA 患者比未治疗的患者表现出更高的 HRU 和成本。

结论

在西班牙进行的一项全国代表性调查中，疼痛的严重程度是 OA 患者 HRU 和费用的主要驱动因素。这些发现似乎在使用常规镇痛剂治疗的患者与未治疗的患者中更为一致。