Plant protection products (PPPs) consist of pesticide active substances and co‐formulants. Generally, active substance effects are assumed to dominate in PPP toxicity. Nevertheless, co‐formulants may well affect the toxicity of PPPs via toxicodynamic and toxicokinetic interaction. To account for potential mixture effects and improve PPP data requirements for application in risk assessment, a tiered test strategy is proposed. The strategy is based on a comparison of PPP and active substance toxicity, which enables the prioritisation of PPPs for further testing, adaptation of the toxicological threshold value or removal of toxic co‐formulants from the PPP. Moreover, it focuses on the integrative assessment of existing information and newly generated data using alternative test methods. The proposed strategy will improve PPP toxicological assessment by accounting for mixture toxicity, providing a set of regulatory options for risk assessment and the necessary data for hazard assessment. The predictivity of alternative methods for PPPs will improve by evaluation of their reliability and uncertainty. © 2020 The Authors. Pest Management Science published by JohnWiley & Sons Ltd on behalf of Society of Chemical Industry.

中文翻译：

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制定一种针对植物保护产品的分级测试策略，以通过人类健康评估中的替代方法解决混合物毒性。

植物保护产品（PPP）由农药活性物质和助剂组成。通常，假定活性物质的作用在PPP毒性中起主要作用。然而，共制剂可能通过毒理动力学和毒代动力学相互作用而很好地影响PPP的毒性。为了解决潜在的混合效应并提高在风险评估中应用的PPP数据要求，提出了一种分层测试策略。该策略基于对PPP和活性物质毒性的比较，从而可以确定PPP的优先级，以进行进一步测试，调整毒理学阈值或从PPP中去除有毒助剂。此外，它着重于使用替代测试方法对现有信息和新生成的数据进行综合评估。拟议的策略将通过考虑混合物的毒性，为风险评估提供一组监管选项以及为危害评估提供必要的数据，从而改善PPP毒理学评估。通过评估PPP的可靠性和不确定性，替代方法的可预测性将会提高。©2020作者。JohnWiley＆Sons Ltd代表化学工业协会出版的《害虫管理科学》。