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Elucidation of phytomedicinal efficacies of Clerodendrum inerme (L.) Gaertn. (Wild Jasmine)
South African Journal of Botany ( IF 3.1 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.sajb.2020.07.027
Pallab Kar , Dipu Kumar Mishra , Ayan Roy , Arnab Kumar Chakraborty , Biswajit Sinha , Arnab Sen

Abstract Clerodendrum inerme is a perennial shrub belonging to the family Lamiaceae and is used in many of the herbal preparations of Siddha and Ayurveda in India. Ethnomedicinally, the leaves of this plant are used to cure various ailments. In spite of enormous ethnomedicinal implications, proper chemical profiling and characterization of isolated compounds of C. inerme still remains unaddressed. Present study involves the characterization and chemical profiling of phytoconstituents from leaf extract which promise to be of immense therapeutic significance. Two compounds namely squalene and linolenic acid methyl ester were isolated from the leaves of C. inerme employing column chromatography technique. The structures were elucidated by spectroscopic methods including FTIR, 1H NMR and 13C NMR. Subsequently, antioxidant and antimicrobial activities of the isolated compounds were estimated in-vitro. Pertaining results were validated with in silico molecular docking-based investigations which revealed that both the compounds displayed high binding affinities with the target proteins of the antioxidant pathway commonly targeted for drug development.

中文翻译:

阐明 Clerodendrum inerme (L.) Gaertn 的植物药效。(野茉莉)

摘要 Clerodendrum inerme 是唇形科的多年生灌木,在印度的悉达 (Siddha) 和阿育吠陀 (Ayurveda) 中被用于许多草药制剂中。在民族医学上,这种植物的叶子用于治疗各种疾病。尽管具有巨大的民族医学意义,C. inerme 分离化合物的适当化学分析和表征仍未得到解决。目前的研究涉及叶提取物中植物成分的表征和化学分析,这些成分有望具有巨大的治疗意义。采用柱层析技术从C. inerme的叶子中分离出两种化合物,即角鲨烯和亚麻酸甲酯。通过光谱方法包括FTIR、1H NMR和13C NMR来阐明结构。随后,在体外评估了分离化合物的抗氧化和抗微生物活性。相关结果通过基于计算机分子对接的研究得到验证,这表明这两种化合物与通常用于药物开发的抗氧化途径的靶蛋白显示出高结合亲和力。
更新日期:2020-08-01
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