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Association between intracranial aneurysm and Meningiomas: an integrative Survival analysis with identification of prognostic factors
Clinical Neurology and Neurosurgery ( IF 1.9 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.clineuro.2020.106128
Matheus Rodrigues de Souza 1 , Caroline Ferreira Fagundes 1 , Nicollas Nunes Rabelo 2 , Manoel Jacobsen Teixeira 3 , Eberval Gadelha Figueiredo 3
Affiliation  

OBJECTIVE To analyze prognostic factors in clinical association between intracranial aneurysm (IA) and meningioma. Prognostic factors on overall survival (OS) were evaluated. METHODS We selected articles, published from January 1944 to December 2018 on the Medical databases (Web of Sciences, Medline and EMBASE) and included case series and reports. Clinical information was obtained and variables associated with the primary outcome of 27-mo survival were identified through Cox regression models. RESULTS The study evaluated 77 patients. Female represented 76.6 % (n = 59), a ratio of 3.27 female: 1 male. The age range was 7-84 years old, with an average of 54.74 (SD: 14.30). Age and sex were not significant statistically different between the two groups for overall survival (OS) (log-rank P = 0.806), (log-rank P = 0.983) respectively. 77.9 % (n = 60) were ipsilateral, the same side was 4 times more common in univariate analysis (P = 0.052; 95 % CI, 0.924-17.319). Most aneurysms were detected in the internal carotid artery, 29.87 %. In Clinical data, 62.33 % (n = 48) had exclusive tumor symptoms, while 25.97 % (n = 20) presented exclusively subarachnoid hemorrhage (SAH). In multivariate analysis, although there is an independent protective factor for those who did not have SAH (HR; 0.099; CI; 0.010-0.986; P = 0.049) and the treatment is an independent predictor for OS (HR, 42.096; CI, 4.270-415.056; P = 0.01). CONCLUSION This is the first study to approach this association. This is not just an occasional finding, but it seems to have a shared pathophysiology. Unruptured aneurysms and treatment modality were protective independent factors for OS. Prospective studies are warranted to provide definitive answers.

中文翻译:

颅内动脉瘤和脑膜瘤之间的关联:综合生存分析与预后因素的识别

目的分析颅内动脉瘤(IA)与脑膜瘤临床关联的预后因素。评估了总生存期 (OS) 的预后因素。方法 我们选择了 1944 年 1 月至 2018 年 12 月发表在医学数据库(Web of Sciences、Medline 和 EMBASE)上的文章,包括病例系列和报告。获得了临床信息,并通过 Cox 回归模型确定了与 27 个月生存率的主要结果相关的变量。结果 该研究评估了 77 名患者。女性占 76.6%(n = 59),比例为 3.27 女性:1 男性。年龄范围7-84岁,平均54.74(SD:14.30)。两组的总生存期(OS)(log-rank P = 0.806),(log-rank P = 0.983)在两组之间的年龄和性别没有显着的统计学差异。77. 9 % (n = 60) 为同侧,单变量分析中同侧的发生率是同侧的 4 倍(P = 0.052;95 % CI,0.924-17.319)。大多数动脉瘤在颈内动脉中检测到,29.87%。在临床数据中,62.33 % (n = 48) 具有独特的肿瘤症状,而 25.97 % (n = 20) 仅表现为蛛网膜下腔出血 (SAH)。在多变量分析中,虽然对于没有 SAH 的患者有一个独立的保护因素(HR;0.099;CI;0.010-0.986;P = 0.049)并且治疗是 OS 的独立预测因子(HR,42.096;CI,4.270 -415.056;P = 0.01)。结论 这是第一个接近这种关联的研究。这不仅仅是一个偶然的发现,而且似乎有一个共同的病理生理学。未破裂的动脉瘤和治疗方式是 OS 的保护性独立因素。
更新日期:2020-11-01
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