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An outbreak of Clostridioides difficile infections due to a 027-like PCR ribotype 181 in a rehabilitation centre: Epidemiological and microbiological characteristics.
Anaerobe ( IF 2.3 ) Pub Date : 2020-08-08 , DOI: 10.1016/j.anaerobe.2020.102252
Melina Kachrimanidou 1 , Amoe Baktash 2 , Symeon Metallidis 3 , Οlga Tsachouridou 3 , Foteini Netsika 1 , Despoina Dimoglou 1 , Angeliki Kassomenaki 1 , Eirini Mouza 4 , Mina Haritonidou 4 , Ed Kuijper 2
Affiliation  

Clostridioides difficile is one of the most important healthcare-associated pathogens. Recently, several new 027-like types have been found that all belong to the multilocus sequence typing (MLST) Clade 2. We report a rapidly spreading outbreak of C. difficile infections (CDI) due to a newly identified PCR ribotype (RT) 181 in a Rehabilitation Centre (RC). Genomic analysis revealed the outbreak strain, not previously identified in Greece, belonged to clade 2, sequence type (ST) 1 and had a 18bp deletion in tcdC at position 311 together with a single nucleotide deletion at position 117, similarly to RT 027. The presence of a clonal outbreak was confirmed by whole genome sequencing, yet the source of this ribotype remained unclear. The emergence and rapid spread of new C. difficile ribotypes highlights the need for ongoing C. difficile surveillance and better understanding of overall Clade 2 phylogeny.



中文翻译:

在康复中心因027样PCR核糖型181导致艰难梭菌感染的爆发:流行病学和微生物学特征。

艰难梭菌是最重要的医疗相关病原体之一。最近,发现了几种新的027样类型,它们都属于多基因座序列分型(MLST)进化枝2。我们报道了由于新鉴定的PCR核型(RT)181 ,艰难梭菌感染(CDI)迅速蔓延在康复中心(RC)。基因组分析显示,该爆发菌株先前未在希腊发现,属于进化枝2,序列类型(ST)1,在tcdC的311位缺失了18bp,在117位具有单核苷酸缺失,类似于RT 027。全基因组测序证实了克隆性暴发的存在,但这种核糖型的来源仍不清楚。新事物的出现和迅速传播艰难梭菌核糖型强调了正在进行的艰难梭菌监测和更好地了解进化枝2总体系统发育的需要。

更新日期:2020-08-08
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