Talinum paniculatum (Jacq.) Gaertn. (Talinaceae), popularly known as “major gomes,” is a Brazilian Cerrado plant used in traditional medicine and as a food source. Recent studies have demonstrated its diuretic effects. However, no studies have been performed on its effects on the reproductive system. Therefore, we aimed to investigate the effects of the ethanol-soluble fraction of T. paniculatum leaves (ESTP) on general toxicity and on the pubertal development of male and female Wistar rats. For this purpose, the uterotrophic and the pubertal assays were performed. In the uterotrophic test, female immature rats were treated for three consecutive days with 30, 100, or 300 mg/kg of ESTP. Uterus without luminal fluid was weighed and the relative weight calculated. For the pubertal assay, male and female immature rats were submitted to 30-day treatment with 30 or 300 mg/kg of ESTP. Clinical signs of toxicity, biochemical, and histopathological parameters were evaluated. ESTP treatment did not promote estrogenic effects in female rats. In the pubertal test, no daily signs of toxicity or weight loss were observed. Moreover, ESTP did not affect the onset of vaginal opening and preputial separation and did not cause significant changes in biochemical parameters as well as in organ weight and histopathological analyses of animals.

Talinum paniculatum (Jacq.) Gaertn. （Talinaceae），俗称“主要果麦”，是一种巴西塞拉多植物，用于传统医学和食物来源。最近的研究证明了它的利尿作用。然而，尚未对其对生殖系统的影响进行研究。因此，我们旨在研究T. paniculatum乙醇可溶部分的影响叶 (ESTP) 对雄性和雌性 Wistar 大鼠的一般毒性和青春期发育的影响。为此，进行了促子宫和青春期测定。在促子宫试验中，雌性未成熟大鼠连续三天接受 30、100 或 300 毫克/千克 ESTP 的治疗。称重没有管腔积液的子宫并计算相对重量。对于青春期试验，雄性和雌性未成熟大鼠接受 30 天或 300 毫克/千克 ESTP 的治疗。评估了毒性、生化和组织病理学参数的临床症状。ESTP 治疗不会促进雌性大鼠的雌激素作用。在青春期试验中，没有观察到每日毒性或体重减轻的迹象。而且，