Background: Chronic heart failure (CHF) is a major health burden worldwide, but there are a lack of effective methods for its early diagnosis and prognostic evaluation. Circular RNAs (circRNA), as a class, have been found to regulate gene expression and are implicated in multiple types of diseases. The circRNA, CDR1as, is reported to regulate gene transcription by acting as a microRNA inhibitor. However, the role of CDR1as in CHF remains to be elucidated. The aim of this study was to investigate the role and mechanism of action of the circRNA, CDR1as, in CHF.

中文翻译：

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环形RNA CDR1as通过miR-135a / HMOX1和miR-135b / HMOX1轴调节人心肌细胞的增殖和凋亡。

背景：慢性心力衰竭（CHF）是世界范围内的主要健康负担，但缺乏对其早期诊断和预后评估的有效方法。环状RNA（circRNA）作为一类，已发现其调节基因表达，并涉及多种类型的疾病。据报道，circRNA CDR1as通过充当microRNA抑制剂来调节基因转录。但是，CDR1as在CHF中的作用仍有待阐明。这项研究的目的是调查circRNA，CDR1as在CHF中的作用和作用机制。