Objective. In this study, considering the importance of platelet function in inflammatory processes, we explored whether there are relationships of platelet indices with postdural puncture headache (PDPH) and pain developing after use of spinal needles and whether patient characteristics contribute to the development of PDPH. Methods. This prospective, observational study included 76 patients (Group 1) with PDPH and 93 patients (Group 2) without PDPH. The postoperative hemoglobin, hematocrit, platelet count (PC), and mean platelet volume (MPV) values were recorded, along with age, blood type, Rh factor, gravida, parity, and gestational age. In addition, the time of the onset of pain was recorded in patients who complained of a postspinal headache. Results. Hemoglobin and hematocrit values in Group 1 were significantly lower than in Group 2 (both, ). The PC of Group 1 was significantly higher than that of Group 2 (), whereas the MPV was significantly lower (). The area under the curve (AUC) values were significant for hemoglobin, hematocrit, PC, and MPV (, , , and , resp.). For MPV, the AUC value was 0.293, sensitivity was 1%, and specificity was 99%. The highest likelihood ratio (LR+) value was 1.22 at a cut-off value of 13.3 fL. For the PC, the AUC value was 0.666, the sensitivity was 9%, and the specificity was 99%, while the highest LR + value was 8.56 at a cut-off value of 352 × 10⁹/L. There was no significant relationship between the parameters examined and the onset of pain. Conclusion. In this study, the PC was higher and MPV was lower in obstetric patients with PDPH compared with the control group. However, we also found that these two values cannot be used as markers of PDPH.

中文翻译：

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血小板计数和平均血小板体积可以用作产科患者硬膜穿刺后头痛的标志吗？

目标。在这项研究中，考虑到血小板功能在炎症过程中的重要性，我们探讨了血小板指数与硬膜后穿刺性头痛（PDPH）和使用脊柱针后疼痛的发展之间是否存在关系，以及患者的特征是否有助于PDPH的发展。方法。这项前瞻性观察性研究包括76例PDPH的患者（第1组）和93例无PDPH的患者（第2组）。记录术后血红蛋白，血细胞比容，血小板计数（PC）和平均血小板体积（MPV）值，以及年龄，血型，Rh因子，妊娠，胎次和胎龄。此外，抱怨脊柱后头痛的患者会记录疼痛发作的时间。结果。第1组的血红蛋白和血细胞比容值显着低于第2组（）。第1组的PC明显高于第2组（），而MPV则明显较低（）。曲线下面积（AUC）值对于血红蛋白，血细胞比容，PC和MPV显着（， ， ，和，分别）。对于MPV，AUC值为0.293，灵敏度为1％，特异性为99％。最高似然比（LR +）值为1.22，截止值为13.3 fL。PC的AUC值为0.666，灵敏度为9％，特异性为99％，而最高LR +值为8.56，截止值为352×10 ⁹ / L。检查的参数与疼痛发作之间没有显着关系。结论。在这项研究中，与对照组相比，PDPH产科患者的PC较高，MPV较低。但是，我们还发现这两个值不能用作PDPH的标记。