The current prevalence of obesity has been linked to the consumption of highly palatable foods and may be mediated by a dysregulated or hyposensitive orosensory perception of dietary fat, thereby contributing to the susceptibility to develop obesity. The goal of the current study was to investigate the role of lingual taste input in obesity-prone (OP, Osborne-Mendel) and obesity-resistant (OR, S5B/Pl) rats on the consumption of a high-fat diet (HFD). Density of fungiform papillae was assessed as a marker of general orosensory input. To determine if orosensory afferent input mediates dietary fat intake, surgical transection of the chorda tympani and glossopharyngeal nerves (GLX/CTX) was performed in OP and OR rats and HFD caloric intake and body weight were measured. Fungiform papillae density was lower in OP rats, compared with OR rats. GLX/CTX decreased orosensory input in both OP and OR rats, as measured by an increase in the intake of a bitter, quinine solution. Consumption of low-fat diet was not altered by GLX/CTX in OP and OR rats; however, GLX/CTX decreased HFD intake in OR, without altering HFD intake in OP rats. Overall, these data suggest that inhibition of orosensory input in OP rats do not decrease fat intake, thereby supporting that idea that hyposensitive and/or dysregulated orosensory perception of highly palatable foods contribute to the susceptibility to develop obesity.

中文翻译：

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味觉神经的横断对易肥胖和抗肥胖大鼠的膳食脂肪摄入量有不同的影响。

目前肥胖症的流行与食用高度可口的食物有关，并且可能是由对膳食脂肪的失调或不敏感的口腔感觉感知介导的，从而导致肥胖的易感性。本研究的目的是研究舌味输入在易肥胖（OP，Osborne-Mendel）和肥胖抵抗（OR，S5B/Pl）大鼠中对高脂肪饮食（HFD）消耗的作用. 菌状乳头的密度被评估为一般口腔感觉输入的标志。为了确定口感觉传入输入是否介导膳食脂肪摄入，在 OP 和 OR 大鼠中进行了鼓索和舌咽神经 (GLX/CTX) 的手术横断，并测量了 HFD 热量摄入和体重。与 OR 大鼠相比，OP 大鼠的真菌状乳头密度较低。GLX/CTX 减少了 OP 和 OR 大鼠的口感觉输入，这是通过增加苦味奎宁溶液的摄入量来衡量的。GLX/CTX 在 OP 和 OR 大鼠中没有改变低脂饮食的消耗；然而，GLX/CTX 减少了 OR 中的 HFD 摄入量，而不会改变 OP 大鼠中的 HFD 摄入量。总体而言，这些数据表明抑制 OP 大鼠的感官输入不会减少脂肪摄入量，从而支持这种观点，即高度可口食物的低敏和/或失调的感官知觉有助于发展肥胖的易感性。