Fatigue and anhedonia are commonly reported, co-occurring clinical symptoms associated with chronic illnesses. Fatigue is a multidimensional construct that is defined as a distressing, persistent, subjective sense of physical, cognitive, or emotional tiredness that interferes with usual functioning. Anhedonia is a component of depressive disorders and other psychiatric conditions, such as schizophrenia, and is defined by the reduced ability to experience pleasure. Both symptoms greatly affect the health-related quality of life of patients with chronic illnesses. Although fatigue and anhedonia are commonly associated with each other, understanding the differences between the two constructs is necessary for diagnosis and clinical treatment. A scoping review was conducted based on published guidance, starting with a comprehensive search of existing literature to understand the similarities and differences between fatigue and anhedonia. An initial search of PubMed using fatigue and anhedonia as medical subject headings yielded a total of 5254 articles. A complete full-text review of the final 21 articles was conducted to find articles that treated both constructs similarly and articles that presented fatigue and anhedonia as distinct constructs. About 60% of the reviewed articles consider both constructs as distinct, but a considerable number of the reviewed articles found these constructs indistinguishable. Nomenclature and biology were two themes from the reviewed articles supporting the idea that anhedonia and fatigue are indistinguishable constructs. The information generated from this review is clinically relevant to optimize the management of fatigue related to anhedonia from other fatigue subtypes.

疲劳和快感缺乏症是普遍报道的，与慢性疾病相关的临床症状同时出现。疲劳是一种多维结构，被定义为干扰正常功能的令人痛苦的，持久的，主观的身体，认知或情感疲劳感。快感缺乏症是抑郁症和其他精神疾病（例如精神分裂症）的组成部分，其定义为体验乐趣的能力降低。两种症状都极大地影响了慢性疾病患者的健康相关生活质量。尽管疲劳和快感缺乏症通常相互关联，但是了解两种结构之间的差异对于诊断和临床治疗是必不可少的。根据已发布的指南进行了范围界定审查，从全面检索现有文献开始，以了解疲劳和快感缺乏之间的异同。使用疲劳和快感缺乏作为医学主题词的PubMed初步搜索共获得5254篇文章。对最后的21篇文章进行了完整的全文审查，以找到对两种构造都进行类似处理的文章以及将疲劳和快感缺乏症作为不同的构造呈现的文章。大约60％的评论文章认为这两种结构是不同的，但是相当数量的评论文章认为这些结构是无法区分的。命名法和生物学是被评价文章中的两个主题，支持了快感和疲劳是无法区分的构想。