Thirty years on from the launch of the Human Genome Project, Richard Gibbs reflects on the promises that this voyage of discovery bore. Its success should be measured by how this project transformed the rules of research, the way of practising biological discovery and the ubiquitous digitization of biological science. Thirty years on from the launch of the Human Genome Project, Richard Gibbs reflects on the promisesthat this voyage of discovery bore. Its success should be measured by how this project transformed the rules of research, the way of practising biological discovery and the ubiquitous digitization of biological science. Richard Gibbs, AC, PhD is a human geneticist and the Founding Director of the Baylor College of Medicine Human Genome Sequencing Center (HGSC). He graduated from the University of Melbourne in Genetics and Radiation Biology and moved to Houston, TX, to study the molecular basis of genetic disease. He developed basic methods for DNA and mutation analysis and was an early contributor to the Human Genome Project (HGP), leading one of five sites that generated the majority of the sequence. Since the completion of the HGP, he has led multiple genome projects including the generation of the first personalized whole-genome diploid human sequences. His group pioneered the oligonucleotide exon-capture methods that are widely used today for whole-exome sequencing, and he is currently leading programmes for translation of genomic data into the clinic.

中文翻译：

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人类基因组计划改变了一切。

理查德·吉布斯（Richard Gibbs）在人类基因组计划启动30年后，反思了这次探索之旅的承诺。它的成功应通过该项目如何改变研究规则，实践生物发现的方式以及普遍存在的生物科学数字化来衡量。理查德·吉布斯（Richard Gibbs）在人类基因组计划启动30年后，反思了这次探索之旅的承诺。它的成功应通过该项目如何改变研究规则，实践生物发现的方式以及普遍存在的生物科学数字化来衡量。Richard Gibbs，AC，博士是人类遗传学家，是贝勒医学院人类基因组测序中心（HGSC）的创始董事。他毕业于墨尔本大学遗传与辐射生物学专业，并迁至德克萨斯州休斯顿，研究遗传疾病的分子基础。他开发了用于DNA和突变分析的基本方法，并且是人类基因组计划（HGP）的早期贡献者，领导了产生大部分序列的五个位点之一。自HGP完成以来，他领导了多个基因组计划，包括第一个个性化全基因组二倍体人类序列的产生。他的小组开创了今天广泛用于全外显子组测序的寡核苷酸外显子捕获方法的先驱，并且他目前正在领导将基因组数据翻译到临床的程序。他开发了用于DNA和突变分析的基本方法，并且是人类基因组计划（HGP）的早期贡献者，领导了产生大部分序列的五个位点之一。自HGP完成以来，他领导了多个基因组计划，包括第一个个性化全基因组二倍体人类序列的产生。他的小组开创了今天广泛用于全外显子组测序的寡核苷酸外显子捕获方法的先驱，并且他目前正在领导将基因组数据翻译到临床的程序。他开发了用于DNA和突变分析的基本方法，并且是人类基因组计划（HGP）的早期贡献者，领导了产生大部分序列的五个位点之一。自HGP完成以来，他领导了多个基因组计划，其中包括第一批个性化全基因组二倍体人类序列的产生。他的小组开创了今天广泛用于全外显子组测序的寡核苷酸外显子捕获方法的先驱，并且他目前正在领导将基因组数据翻译到临床的程序。