Materials Technology ( IF 3.1 ) Pub Date : 2020-08-07 , DOI: 10.1080/10667857.2020.1802839 Prakash N. Kendre 1 , Gayatri Dusane 2 , Shirish P. Jain 3 , Mahendra A. Giri 2 , Ajinkya K. Pote 1
ABSTRACT
Drug release properties for transdermal route can be better modified as per requirement which is mostly dependent upon the carrier system. In case of organic film-forming systems, the physical properties may not be achieved for successful delivery of drug through transdermal route. A novel organic-inorganic hybrid film-forming gel may fulfil these expectations to many extend. The present study focuses on the development of the organic-inorganic hybrid film-forming gel. A smooth, transparent, clear film-forming gel of tramadol was prepared for application on the intact skin with better comfort and modified drug release rate properties. The key properties of the adhesive films produced from the hybrid gels were investigated and the results showed that the incorporation of appropriate PVA: TEOS: Glycerine: HCl in the ratio of 46:12.5:25.5:6 respectively. Resultant hybrid film-forming gel has modified the physical properties and improved drug release properties. Furthermore, the investigations of skin irritation suggested no irritation to skin after topical application. This study has provided an alternative to the presently available organic gel and films for transdermal delivery of drugs with better patient compliance and modified physical and chemical stability.
中文翻译:
定制混合有机-无机成膜外用凝胶:盐酸曲马多给药的可调方法
摘要
透皮途径的药物释放特性可以根据需要进行更好的修改,这主要取决于载体系统。在有机成膜系统的情况下,可能无法通过透皮途径成功递送药物的物理特性。一种新型的有机-无机混合成膜凝胶可以在很多方面满足这些期望。目前的研究重点是有机-无机混合成膜凝胶的开发。制备了一种光滑、透明、透明的曲马多成膜凝胶,用于具有更好的舒适度和改进的药物释放速率特性的完整皮肤。研究了由混合凝胶生产的粘合膜的关键特性,结果表明,以 46:12.5:25.5: 的比例加入适当的 PVA: TEOS: 甘油: HCl: 6 分别。所得混合成膜凝胶改善了物理特性并改善了药物释放特性。此外,对皮肤刺激的研究表明,局部应用后对皮肤没有刺激。这项研究为目前可用的有机凝胶和薄膜提供了一种替代方案,用于透皮给药的药物具有更好的患者依从性和改进的物理和化学稳定性。