Introduction: Atopic dermatitis (AD) is a chronic inflammatory disease that begins in early childhood. Sleep problems have increased in children with AD. The aim of this study was to evaluate sleep patterns and the development of children with AD at an early age. Methods: This is a cross-sectional study consisting of a total of 80 children aged 0–36 months with AD. Patients were evaluated by the Brief Infant Sleep Questionnaire and International Guide for Monitoring Child Development. Results: The median age (IQR) of the patients was 6 (4.25–9) months, 63.7% of them were male and 50% of them had sleep problems. Male sex (OR: 3.78, p = 0.024, 95% CI, 0.083–0.837), patients with AD who were in the first 3 months after diagnosis (OR: 3.56; 95% CI, 1.220–10.43, p = 0.020), and moderate-severe AD (OR: 5.09; 95% CI, 1.649–15.748, p = 0.005) were determined as risk factors for sleep problems. In all, 12.5% of the patients needed support for one or more developmental areas (gross motor skills, expressive language and communication, receptive language, fine motor skills, relationship, and play). Developmental delay was higher in patients with sleep problems (p = 0.037). Multiple siblings (OR: 14.381; 95% CI, 1.557–132.871, p = 0.019) and the presence of sleep problems (OR: 8.011; 95% CI, 1.764–36.387, p = 0.024) were found to be risk factors for developmental delay. Conclusion: Boys with moderate-severe AD within the first 3 months of diagnosis were at increased risk for sleep problems. Children with AD who have multiple siblings and sleep problems should be evaluated for developmental delay and monitored closely.
Int Arch Allergy Immunol

中文翻译：

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特应性皮炎儿童的睡眠模式和发育。

简介：特应性皮炎（AD）是一种慢性炎性疾病，始于儿童早期。AD儿童的睡眠问题增加了。这项研究的目的是评估儿童的睡眠模式和儿童AD的发育。方法：这是一项横断面研究，由80位0-36个月大的AD儿童组成。通过《简短婴儿睡眠调查表》和《国际儿童发育监测指南》对患者进行了评估。结果：患者的中位年龄（IQR）为6（4.25–9）个月，其中63.7％是男性，其中50％有睡眠问题。男性（OR：3.78， p= 0.024、95％CI，0.083-0.837），诊断后头三个月内的AD患者（OR：3.56； 95％CI，1.220-10.43，p = 0.020）和中度重度AD（OR： 5.09； 95％CI（1.649–15.748，p = 0.005）被确定为睡眠问题的危险因素。总体而言，12.5％的患者需要一个或多个发展领域的支持（运动技能，表达语言和沟通能力，接受语言，精细运动技能，人际关系和游戏能力）。有睡眠问题的患者发育延迟较高（p = 0.037）。多个同胞（OR：14.381; 95％CI，1.557–132.871，p = 0.019）和存在睡眠问题（OR：8.011; 95％CI，1.764–36.387，p= 0.024）是发育迟缓的危险因素。结论：在诊断的前3个月内患有中度重度AD的男孩的睡眠问题风险增加。患有多个兄弟姐妹和睡眠问题的AD儿童应评估发育延迟并进行密切监测。
Int Arch过敏免疫