Abstract The citrate-based thermoset elastomer is a promising candidate for bone scaffold material, but the harsh curing condition made it difficult to fabricate porous structure. Recently, poly (1, 8-octanediol-co-Pluronic F127 citrate) (POFC) porous scaffold was creatively fabricated by chitin nanofibrils (ChiNFs) supported emulsion-freeze-casting. Thanks to the supporting role of ChiNFs, the lamellar pore structure formed by directional freeze-drying was maintained during the subsequent thermocuring. Herein, bioactive glass (BG) was introduced into the POFC porous scaffolds to improve bioactivity. It was found the complete replacement of ChiNF particles with BG particles could not form a stable porous structure; however, existing at least 15 wt% ChiNF could ensure the formation of lamellar pore, and the interlamellar distance increased with BG ratios. Thus, the BG granules did not contribute to the formation of pore structure like ChiNFs, however, they surely endowed the scaffolds with enhanced mechanical properties, improved osteogenesis bioactivity, better cytocompatibility as well as quick degradation rate. Reasonably adjusting BG ratios could balance the requirements of porous structure and bioactivity.

中文翻译：

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通过定向冷冻浇铸制备聚（1, 8-辛二醇-co-Pluronic F127 柠檬酸盐）/几丁质纳米纤维/生物活性玻璃（POFC/ChiNF/BG）多孔支架

摘要 柠檬酸盐基热固性弹性体是一种很有前景的骨支架材料，但其固化条件苛刻，难以制备多孔结构。最近，聚（1, 8-辛二醇-co-Pluronic F127 柠檬酸盐）（POFC）多孔支架由几丁质纳米纤维（ChiNFs）支持的乳液冷冻浇铸创造性地制造。由于 ChiNFs 的支持作用，定向冷冻干燥形成的层状孔结构在随后的热固化过程中得以保持。在此，生物活性玻璃（BG）被引入到 POFC 多孔支架中以提高生物活性。发现用BG颗粒完全取代ChiNF颗粒不能形成稳定的多孔结构；然而，存在至少 15 wt% ChiNF 可以确保层状孔的形成，并且层间距离随着BG比率增加。因此，BG 颗粒不像 ChiNFs 那样有助于孔结构的形成，然而，它们确实赋予支架增强的机械性能、改善的成骨生物活性、更好的细胞相容性以及快速的降解速率。合理调整BG比例可以平衡多孔结构和生物活性的要求。