Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g., dissolution, solubility, stability) in solid dispersions. Various prominent reviews on solid dispersions have been reported recently. However, there is still no overview of recent techniques for evaluating the molecular interactions that occur within solid dispersions of poorly water-soluble drugs. In this review, we aim to overview common methods that have been used for solid dispersions to identify different bond formations and forces via the determination of interaction energy. In addition, a brief background on the important role of molecular interactions will also be described. The summary and discussion of methods used in the determination of molecular interactions will contribute to further developments in solid dispersions, especially for quick and potent drug delivery applications.

中文翻译：

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水溶性差的药物在固体分散体中的分子相互作用。

物理化学表征是成功开发固体分散体（包括确定药物结晶度和分子相互作用）的关键步骤。通常，分子相互作用的检测将有助于解释固体分散体中不同的药物性能（例如，溶解度，溶解度，稳定性）。最近已经报道了关于固体分散体的各种著名评论。然而，仍然没有用于评估水溶性差的药物的固体分散体中发生的分子相互作用的最新技术的概述。在这篇综述中，我们旨在概述用于固体分散体的通用方法，这些方法通过确定相互作用能来确定不同的键形成和作用力。此外，还将简要介绍分子相互作用的重要作用。用于确定分子相互作用的方法的总结和讨论将有助于固体分散体的进一步发展，特别是对于快速有效的药物递送应用。