The Effect of the Supplementation of a Diet Low in Calcium and Phosphorus with Either Sheep Milk or Cow Milk on the Physical and Mechanical Characteristics of Bone using A Rat Model.,Foods

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The Effect of the Supplementation of a Diet Low in Calcium and Phosphorus with Either Sheep Milk or Cow Milk on the Physical and Mechanical Characteristics of Bone using A Rat Model.
Foods ( IF 5.2 ) Pub Date : 2020-08-07 , DOI: 10.3390/foods9081070
Keegan Burrow ₁ , Wayne Young _{2,

3} , Niels Hammer _{4,

5,

6} , Sarah Safavi ₇ , Mario Scholze ₈ , Michelle McConnell ₉ , Alan Carne ₁₀ , David Barr ₁₁ , Malcolm Reid ₁₁ , Alaa El-Din Bekhit ₁₂

Affiliation

Department of Wine, Food and Molecular Biosciences, Lincoln University, PO Box 85084, Lincoln 7647, New Zealand.
AgResearch Ltd, Grasslands Research Centre, Private Bag 11008, Manawatu Mail Centre, Palmerston North 4442, New Zealand.
Riddet Institute, Massey University, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand.
Department of Macroscopic and Clinical Anatomy, Medical University of Graz, 8010 Graz, Austria.
Department of Orthopaedic and Trauma Surgery, University of Leipzig, Liebigstraße 20, 04103 Leipzig, Germany.
Fraunhofer IWU, Nöthnitzer Straße 44, 01187 Dresden, Germany.
Department of Anatomy, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
Institute of Materials Science and Engineering, Chemnitz University of Technology, Straße der Nationen, 62, 09111 Chemnitz, Germany.
Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
Department of Chemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
Department of Food Science, University of Otago, PO Box 56, Dunedin 9054, New Zealand.

This study assessed the effect of cow milk (CM) and sheep milk (SM) consumption on the micro-structure, mechanical function, and mineral composition of rat femora in a male weanling rat model. Male weanling rats were fed a basal diet with a 50% reduction in calcium and phosphorus content (low Ca/P-diet) supplemented with either SM or CM. Rats were fed for 28 days, after which the femora were harvested and stored. The femora were analyzed by μ-CT, three-point bending, and inductively coupled plasma–mass spectrometry (ICP-MS). The addition of either milk to the low Ca/P-diet significantly increased (p < 0.05) trabecular bone volume, trabecular bone surface density, trabecular number, cortical bone volume, and maximum force, when compared to rats that consumed only the low Ca/P-diet. The consumption of either milk resulted in a significant decrease (p < 0.05) in trabecular pattern factor, and cortical bone surface to volume ratio when compared to rats that consumed only the low Ca/P-diet. The results were achieved with a lower consumption of SM compared to that of CM (p < 0.05). This work indicates that SM and CM can help overcome the effects on bone of a restriction in calcium and phosphorus intake.

中文翻译：

用大鼠模型补充低钙低磷饮食与羊奶或牛乳对骨骼的物理和机械特性的影响。

这项研究评估了雄性断奶大鼠模型中食用牛奶（CM）和绵羊奶（SM）对大鼠股骨的微观结构，机械功能和矿物质组成的影响。给雄性断奶的老鼠喂食基础饮食，钙和磷含量降低50％（低Ca / P饮食），并补充SM或CM。给大鼠喂食28天，然后收获并储存股骨。通过μ-CT，三点弯曲和电感耦合等离子体质谱法（ICP-MS）对股骨进行分析。在低钙/磷饮食中添加两种牛奶都会显着增加（p<0.05）与仅消耗低Ca / P饮食的大鼠相比，骨小梁的骨量，骨小梁的表面密度，骨小梁的数量，皮质骨的体积和最大力量。与仅消耗低Ca / P饮食的大鼠相比，食用两种牛奶都会导致小梁模式因子和皮质骨表面体积比的显着降低（p <0.05）。与CM相比，SM的消耗量较低，从而获得了结果（p <0.05）。这项工作表明SM和CM可以帮助克服钙和磷摄入限制对骨骼的影响。

更新日期：2020-08-08

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