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SGK1 is a signalling hub that controls protein synthesis and proliferation in endothelial cells
FEBS Letters ( IF 3.5 ) Pub Date : 2020-08-20 , DOI: 10.1002/1873-3468.13901
Ferran Medina-Jover 1, 2 , Núria Gendrau-Sanclemente 1, 2 , Francesc Viñals 1, 2, 3
Affiliation  

BMP9 is a cytokine involved in the maturation phase of the angiogenic process that signals through its serine/threonine receptor ALK1 and its coreceptor endoglin. In this paper, we explain how BMP9 directs the regulation of endothelial cell proliferation blockage while in turn stimulating protein synthesis. To achieve this, BMP9 promotes SGK1 synthesis and activation through mTORC2 in order to stimulate the mTORC1/S6K/S6 axis. Moreover, BMP9 blocks proliferation also through SGK1 by reducing the activity of the MEK/ERK signalling pathway. Inhibition of SGK1 activity is sufficient to prevent BMP9‐mediated inhibition of ERK, leading to an increase in endothelial cell proliferation. Overall, our findings reveal that SGK1 is a key player during angiogenesis, mediating the pro‐quiescent and maturation effects of BMP9/ALK1.

中文翻译:

SGK1 是控制内皮细胞蛋白质合成和增殖的信号中枢

BMP9 是一种参与血管生成过程成熟阶段的细胞因子,通过其丝氨酸/苏氨酸受体 ALK1 及其辅助受体内皮糖蛋白发出信号。在本文中,我们解释了 BMP9 如何指导内皮细胞增殖阻断的调节,同时又刺激蛋白质合成。为此,BMP9 通过 mTORC2 促进 SGK1 的合成和激活,以刺激 mTORC1/S6K/S6 轴。此外,BMP9 还通过降低 MEK/ERK 信号通路的活性,通过 SGK1 阻断增殖。抑制 SGK1 活性足以阻止 BMP9 介导的 ERK 抑制,导致内皮细胞增殖增加。总体而言,我们的研究结果表明,SGK1 是血管生成过程中的关键参与者,介导 BMP9/ALK1 的静态和成熟效应。
更新日期:2020-08-20
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