Glycation is a common non‐enzymatic reaction between proteins and sugars, resulting in the formation of advanced glycation end products (AGEs) in the human body. As can be seen in diabetic patients, the accumulation of AGEs in the skin has aesthetic consequences (wrinkles, brown spots and yellowish complexion). Therefore, the objective of this work was to find compounds isolated from natural sources that could eliminate the final AGEs accumulated in the skin with ageing.

中文翻译：

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2,5-二酮哌嗪可减轻人类真皮成纤维细胞中随着年龄增长而积累的晚期糖基化终产物的数量。

糖化是蛋白质和糖之间常见的非酶促反应，导致人体内形成晚期糖基化终产物（AGEs）。正如在糖尿病患者中所见，AGEs 在皮肤中的积累会产生审美后果（皱纹、褐斑和肤色发黄）。因此，这项工作的目的是寻找从天然来源中分离出来的化合物，这些化合物可以消除随着年龄增长而积聚在皮肤中的最终 AGEs。