Stimuli‐responsive materials have received considerable attention for their application in biomedical fields. Herein, the temperature‐dependent phase transition behavior of acetylated polyrotaxanes (Ac‐PRXs) consisting of acetylated cyclodextrins threaded onto a linear axle polymer in aqueous solution is investigated. The aqueous solutions of Ac‐PRXs exhibit temperature‐dependent transmittance changes when the degree of acetylation is 30–40%. Upon increasing the temperature, Ac‐PRXs are dehydrated and acetyl groups are subsequently associated through hydrophobic interactions. Interestingly, the Ac‐PRXs form coacervate droplets with a diameter of ≈2–3 µm above their cloud points. These temperature‐responsivities of Ac‐PRXs are observed for other PRXs with different axle polymer molecular weights and compositions. Consequently, the acetylation of PRXs is an attractive chemical modification for yielding temperature‐responsivities, and Ac‐PRXs can be applied as temperature‐responsive supramolecular materials.

中文翻译：

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环糊精-螺纹聚轮烷的乙酰化可产生温度响应相变和凝聚层形成特性。

刺激响应材料在生物医学领域的应用受到了广泛的关注。在本文中，研究了由乙酰化环糊精组成的乙酰化聚轮烷（Ac-PRXs）随温度变化的相变行为，该乙酰化环糊精拧入水溶液中的线性轴聚合物。当乙酰化度为30–40％时，Ac‐PRX的水溶液显示出随温度变化的透射率变化。随着温度的升高，Ac-PRXs脱水，随后通过疏水相互作用使乙酰基结合。有趣的是，Ac‐PRXs形成凝聚液滴，其凝聚点上方的直径约为2-3 µm。对于其他具有不同轴聚合物分子量和组成的PRX，可以观察到Ac-PRX的这些温度响应性。所以，