We investigated the effect of type 2 diabetes mellitus (T2DM) on respiratory muscle blood flow (BF) during exercise. Using the Goto-Kakizaki (GK) rat model of T2DM, we hypothesized that diaphragm, intercostal and transverse abdominis BFs (radiolabeled microspheres) would be higher in male GK rats (n = 10) compared to healthy male Wistar controls (CON; n = 8) during submaximal exercise (20 m/min, 10% grade). Blood glucose was significantly higher in GK (246 ± 29 mg/dL) compared to CON (103 ± 4 mg/dL; P < 0.01). Respiratory muscle BFs were not different at rest (P > 0.50). From rest to submaximal exercise, respiratory muscle BFs increased in both groups to all muscles (P < 0.01). During submaximal exercise GK rats had higher diaphragm BFs (GK: 189 ± 13; CON: 138 ± 14 mL/min/100 g, P < 0.01), and vascular conductance (GK: 1.4 ± 0.1; CON: 1.0 ± 0.1 ml/min/mmHg/100 g; P < 0.01) compared to CON. There were no differences in intercostal or transverse abdominis BF or VC during exercise (P > 0.15). These findings suggest that submaximal exercise requires a higher diaphragm BF and VC in T2DM compared to healthy counterparts.

我们调查了运动期间 2 型糖尿病 (T2DM) 对呼吸肌血流量 (BF) 的影响。使用 T2DM 的 Goto-Kakizaki (GK) 大鼠模型，我们假设雄性 GK 大鼠 ( n  = 10) 与健康雄性 Wistar 对照组 (CON; n = 8) 在次最大运动期间（20 m/min，10% 坡度）。与 CON (103 ± 4 mg/dL; P < 0.01) 相比，GK (246 ± 29 mg/dL) 的血糖显着升高。呼吸肌BFs 在休息时没有差异（P > 0.50）。从休息到次极量运动，两组呼吸肌BFs均增加至所有肌肉（P < 0.01）。在次极量运动期间，GK 大鼠的膈肌 BF（GK：189 ± 13；CON：138 ± 14 mL/min/100 g，P < 0.01）和血管电导（GK：1.4 ± 0.1；CON：1.0 ± 0.1 ml/ min/mmHg/100 g；P < 0.01) 与 CON 相比。运动期间肋间或腹横肌BF或VC无差异（P> 0.15）。这些研究结果表明，与健康同行相比，T2DM 中的次最大运动需要更高的横膈膜 BF 和 VC。