A dose-response study was made of the broad-spectrum gonadal steroid agonist tibolone (TBL) on lordosis behavior in estradiol benzoate (EB: 5 µg) primed rats. Doses of TBL (0, 1, 4, and 16 μg) were infused to the right lateral ventricle 2 h before testing. The highest dose increased lordosis quotients significantly at 240 min and 360 min following infusion. However, the intensity of lordosis was weak. In experiment 2, the TBL dose of 16 µg was selected to determine whether tamoxifen (TMX), RU486, or antide could modify the lordosis response to TBL. Infusions of the three compounds, before TBL, significantly attenuated the TBL-induced facilitation of lordosis. The results suggest that TBL stimulates lordosis by activating estrogen, progesterone, and may do so by downstream stimulation of GnRH release. The physiological role TBL plays in controlling lordosis behavior remains to be determined.

广谱性腺类固醇激动剂替勃龙（TBL）对苯甲酸雌二醇（EB：5 µg）致敏大鼠的脊柱前凸行为进行了剂量反应研究。在测试前2小时，将TBL剂量（0、1、4和16μg）注入右心室。最高剂量在输注后240分钟和360分钟时显着增加脊柱前凸商。但是，脊柱前凸的强度较弱。在实验2中，选择16 µg的TBL剂量来确定他莫昔芬（TMX），RU486或Antide是否可以改变脊柱前凸对TBL的反应。在TBL之前输注这三种化合物可显着减弱TBL诱导的脊柱前凸的促进作用。结果表明，TBL通过激活雌激素，孕酮来刺激脊柱前凸，并且可能通过下游刺激GnRH释放来刺激。