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The endocrinological component and signaling pathways associated to cardiac hypertrophy.
Molecular and Cellular Endocrinology ( IF 4.1 ) Pub Date : 2020-08-07 , DOI: 10.1016/j.mce.2020.110972
Ana Paula Cremasco Takano 1 , Nathalia Senger 1 , Maria Luiza M Barreto-Chaves 1
Affiliation  

Although myocardial growth corresponds to an adaptive response to maintain cardiac contractile function, the cardiac hypertrophy is a condition that occurs in many cardiovascular diseases and typically precedes the onset of heart failure. Different endocrine factors such as thyroid hormones, insulin, insulin-like growth factor 1 (IGF-1), angiotensin II (Ang II), endothelin (ET-1), catecholamines, estrogen, among others represent important stimuli to cardiomyocyte hypertrophy. Thus, numerous endocrine disorders manifested as changes in the local environment or multiple organ systems are especially important in the context of progression from cardiac hypertrophy to heart failure. Based on that information, this review summarizes experimental findings regarding the influence of such hormones upon signalling pathways associated with cardiac hypertrophy. Understanding mechanisms through which hormones differentially regulate cardiac hypertrophy could open ways to obtain therapeutic approaches that contribute to prevent or delay the onset of heart failure related to endocrine diseases.



中文翻译:

与心脏肥大相关的内分泌成分和信号通路。

尽管心肌生长对应于维持心脏收缩功能的适应性反应,但是心脏肥大是许多心血管疾病中发生的疾病,通常先于心力衰竭发作。不同的内分泌因子,例如甲状腺激素,胰岛素,胰岛素样生长因子1(IGF-1),血管紧张素II(Ang II),内皮素(ET-1),儿茶酚胺,雌激素等,代表了对心肌肥大的重要刺激。因此,在从心脏肥大发展为心力衰竭的情况下,许多表现为局部环境或多个器官系统变化的内分泌疾病特别重要。根据这些信息,这篇综述总结了有关这些激素对与心脏肥大相关的信号通路的影响的实验发现。理解激素差异调节心脏肥大的机制可能会开辟途径,以获取有助于预防或延迟与内分泌疾病有关的心力衰竭发作的治疗方法。

更新日期:2020-08-08
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