Flash vacuum pyrolysis (FVP) of twelve acetylenic amides was investigated. Products of pyrolysis were analyzed, characterized, and mechanisms for their thermal behavior were suggested. The mechanistic approach was determined by the nature of the substituents at the nitrogen of the amide moiety. This study provides a synthetically useful application for the synthesis of 1-azaazulen-2-ones and other unsaturated lactams via FVP of acetylenic amides. The biological activity of selected substrates and their pyrolysis products against MDA-MB-231 breast cancer cells was assessed.

中文翻译：

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乙炔酰胺的闪蒸真空热解：机理研究

研究了十二种炔属酰胺的快速真空热解（FVP）。对热解产物进行了分析，表征，并提出了其热行为的机理。机械方法由酰胺部分氮上取代基的性质决定。这项研究为通过乙炔酰胺的FVP合成1-azaazulen-2-ones和其他不饱和内酰胺提供了合成有用的应用。评估了选定的底物及其热解产物对MDA-MB-231乳腺癌细胞的生物活性。