Pleurotus citrinopileatus(P. citrinopileatus) is a precious medicinal fungus. A novel polysaccharide (CMP) was separated from the mycelia of P. citrinopileatus. The CMP is a neutral polysaccharide with Mw of 3.22 × 10⁶ Da. The CMP is composed of d-Mannose, d-Glucose and d-Galactose with molar ratio of 0.33:1.03:0.21. The backbone of CMP is composed of →3)-α-D-Glcp-(1→ and →3, 6)-α-D-Glcp-(1→, while branches contain →3)-α-D-Manp-(1→ and →3)-β-D-Galp-(1 → . The surface morphology of CMP is smooth with irregular fragmented structure. The IC₅₀ value of CMP is 0.371 mg/mL. Compared with acarbose (0.289 mg/mL), it suggest that CMP has effectively inhibition on α-glucosidase and the inhibition type is Mixed Type inhibition. The CMP can significantly promote the uptake of glucose and the synthesis of glycogen to regulate the insulin resistance of HepG2 insulin resistance cells (HepG2-IR). The regulation of insulin resistance in HepG2-IR cells by CMP is through Pi3K/Akt pathway. The manuscript provide the alternative of polysaccharides from P. citrinopileatus fruiting bodies and develop new substance for hypoglycemic food.

杏鲍菇（P. citrinopileatus）是一种珍贵的药用真菌。从柑桔疟原虫的菌丝体中分离出一种新型多糖（CMP）。CMP是Mw为3.22×10 ⁶  Da的中性多糖。CMP由d-甘露糖，d-葡萄糖和d-半乳糖组成，摩尔比为0.33：1.03：0.21。CMP的骨架由→3）-α-d-GLC的p - （1→和→3,6）-α-d-GLC p - （1→，而分支包含→3）-α-D-曼p - （1→和→3）-β-d-Gal的p - （1→CMP的表面形态是不规则的结构分散平滑ICCMP的₅₀值为0.371mg / mL。与阿卡波糖（0.289 mg / mL）相比，表明CMP对α-葡萄糖苷酶具有有效的抑制作用，抑制类型为混合型抑制。CMP可以显着促进葡萄糖的摄取和糖原的合成，从而调节HepG2胰岛素抵抗细胞（HepG2-IR）的胰岛素抵抗。CMP对HepG2-IR细胞中胰岛素抵抗的调节是通过Pi3K / Akt途径进行的。该手稿提供了P. citrinopileatus子实体的多糖的替代品，并开发了用于降血糖食品的新物质。