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Mediator subunit MED25: at the nexus of jasmonate signaling.
Current Opinion in Plant Biology ( IF 9.5 ) Pub Date : 2020-08-07 , DOI: 10.1016/j.pbi.2020.06.006
Qingzhe Zhai 1 , Lei Deng 2 , Chuanyou Li 1
Affiliation  

Upon perception by plant cells, the immunity hormone jasmonate (JA) triggers a genome-wide transcriptional program, which is largely regulated by the master transcription factor MYC2. The function of MYC2 depends on its physical and functional interaction with MED25, a subunit of the Mediator transcriptional co-activator complex. In addition to interacting with MYC2 and RNA polymerase II for preinitiation complex formation, MED25 also interacts with multiple genetic and epigenetic regulators and controls almost every step of MYC2-dependent transcription, including nuclear hormone receptor activation, epigenetic regulation, mRNA processing, transcriptional termination, and chromatin loop formation. These diversified functions have ascribed MED25 to a signal-processing and signal-integrating center during JA-regulated gene transcription. This review is focused on the interactions of MED25 with diverse transcriptional regulators and how these mechanistic interactions contribute to the initiation, amplification, and fine tuning of the transcriptional output of JA signaling.



中文翻译:

介体亚基MED25:在茉莉酸酯信号传导的联系。

一旦被植物细胞感知,免疫激素茉莉酸酯(JA)就会触发全基因组转录程序,该程序主要受主转录因子MYC2调控。MYC2的功能取决于它与MED25(介体转录共激活因子复合体的亚基)的物理和功能相互作用。除了与MYC2和RNA聚合酶II相互作用以预先形成复合物外,MED25还与多种遗传和表观遗传调控因子相互作用,并控制MYC2依赖性转录的几乎每个步骤,包括核激素受体激活,表观遗传调控,mRNA加工,转录终止,和染色质环的形成。这些多样化的功能已将MED25归因于JA调控的基因转录过程中的信号处理和信号整合中心。

更新日期:2020-08-08
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