The tumor/infection-impaired skin regeneration is still a challenge and the single modal therapy strategy is usually inefficient. Herein, a multimodal tumor therapy and antiinfection method based on the conductive multifunctional poly(glycerol-amino acid)-based scaffolds is reported. The multifunctional conductive scaffolds were formed through the crosslinking between branched poly(glycerol-amino acid), polypyrrole@polydopamine (PPy@PDA) nanoparticles and aldehyde F127 (PGFP scaffolds). PGFP scaffolds possessed controlled electrical conductivity, skin-adhesive behavior, broad-spectrum antibacterial activity, photothermal-responsive drug release and good cytocompatibility. Thus, PGFP scaffolds demonstrated the significant photothermo-chemo tumor and multidrug resistant infection therapy in vitro and in vivo, while promoting granulation tissue formation, collagen deposition, vascular endothelial differentiation and accelerated skin regeneration. This work also firstly demonstrated the important role of multifunctional conductive PPy@PDA nanoparticles in tumor/infection-impaired skin multimodal therapy. This study suggests that efficient multimodal therapy on diseased-impaired skin could be achieved through optimizing the structure and multifunctional properties of biomaterials.

肿瘤/感染受损的皮肤再生仍然是一个挑战，单模态治疗策略通常效率低下。在此，报道了基于导电性的基于多功能聚（甘油-氨基酸）的支架的多峰肿瘤治疗和抗感染方法。通过支化聚（甘油-氨基酸），聚吡咯@聚多巴胺（PPy @ PDA）纳米颗粒和醛F127（PGFP支架）之间的交联形成多功能导电支架。PGFP支架具有可控的电导率，皮肤粘附行为，广谱抗菌活性，光热响应性药物释放和良好的细胞相容性。因此，PGFP支架在体外和体外均表现出了显着的光化学疗法肿瘤和多药耐药性感染疗法。在体内，同时促进肉芽组织形成，胶原蛋白沉积，血管内皮分化和加速皮肤再生。这项工作还首先证明了多功能导电PPy @ PDA纳米颗粒在肿瘤/感染受损的皮肤多式联运疗法中的重要作用。这项研究表明，可以通过优化生物材料的结构和多功能特性，对患病的皮肤进行有效的多峰疗法。