Abstract

A thermal-responsive Y-shaped amphiphilic block copolymer, namely poly(N-isopropylacrylamide-block-[poly(ε-caprolactone)]₂ (PNIPAAm-b-PCL₂), was synthesized through the combination of atom transfer radical polymerization (ATRP) and ring-opening polymerization (ROP) techniques, and its potential as smart anti-cancer drug delivery system was investigated preliminary. The fabricated polymers were characterized using FTIR and ¹H NMR spectroscopy, and GPC analysis. The self-assembly behavior of the fabricated PNIPAAm-b-PCL₂ copolymer under thermal stimuli was investigated using dynamic light scattering and UV–Vis spectroscopy. The lower critical solution temperature of the synthesized PNIPAAm-b-PCL₂ was found to be 39–41°C. The doxorubicin hydrochloride loading and encapsulation capacities of the fabricated PNIPAAm-b-PCL₂ were calculated to be 62 ± 3%, and 75 ± 4%, respectively; the drug release value was up to 46.5% during 40 h at 37°C and up to 88% at 40°C.

中文翻译：

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由聚ε-己内酯和聚N-异丙基丙烯酰胺组成的热响应Y型Miktoarm两亲嵌段共聚物，作为纳米胶束载体，用于抗癌药物

摘要

通过原子转移自由基聚合（ATRP）的结合，合成了一种热响应性Y型两亲嵌段共聚物，即聚（N-异丙基丙烯酰胺-嵌段-[聚（ε-己内酯）] ₂（PNIPAAm- b -PCL ₂） ）和开环聚合（ROP）技术，并初步研究了其作为智能抗癌药物递送系统的潜力，并通过FTIR和¹ H NMR光谱以及GPC分析对所制备的聚合物进行了表征。人造PNIPAAm- b -PCL ₂使用动态光散射和UV-Vis光谱研究了热刺激下的共聚物。合成PNIPAAm-的低临界溶解温度b -PCL ₂被发现是39-41℃。所制备的PNIPAAm- b -PCL _2的盐酸阿霉素负载量和包封能力分别为62±3％和75±4％。在37°C的40小时内，药物释放值高达46.5％，在40°C的情况下高达88％。